Amitriptyline is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, Amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, Amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as Amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e. g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).
Other names for this medication:
Amitriptyline,
Elavil,
Amineurin,
Amitril,
Amitrip,
Amitriptilina,
Anapsique,
Deprelio,
Eliwel,
Laroxyl,
Lentizol,
Levate,
Mutabase,
Mutabon,
Redomex,
Saroten,
Sarotena,
Sarotex,
Tryptanol,
Tryptizol,
Similar Products:
Zoloral,
Clavor,
Fexofenadin,
Paroxetine,
Efloran,
Nexiam,
Aciclovirum,
Tolep,
Oxactin,
Megaset,
Mesyrel,
Norsic,
Xiclovir,
Omezyn,
Esita,
Lamisil,
Becilan,
Vilerm,
Viraban,
Amoxicilina,
Peptac,
Baktar,
Restream,
Amoxycillin,
Rabeprazole,
Zolen,
Pratiprazol,
Pacifen,
Nexe,
Gastrazol,
Albenza,
Moxicillin,
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Endovascular treatment of descending thoracic aortic rupture: mid- to long-term results in a single-centre registry. Size-adjustable titanium plate for reconstruction of the sella turcica. Wave I latencies of all MMC subgroups were not significantly different from the results of the normal probands. EQ-5D-5L and EQ- visual analogue scale (EQ-VAS) were used to assess HRQOL. For both types megamox antibiotic dosage for tooth of treatment, we found that the cost of signaling decreased as the quality of the signaler increased, demonstrating that the yeast pheromone signal has the key property required for selection under the handicap principle.