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Apydan (Oxcarbazepine)

Apydan is a homologue of the well-known antiepileptic drug carbamazepine. It was developed as an alternative to carbamazepine for patients who had adverse reaction to carbamazepine or diphenylhydantoin. Despite its structural similarities, Apydan differs from carbamazepine in pharmacokinetic behavior, biotransformation profile, and interaction potential. Apydan is like carbamazepine in its mechanisms of action and antiepileptic efficacy but has better tolerability and fewer interactions with other drugs. Most of the clinical development took place during the early 1990s, when it received approval in several countries. It was approved by the FDA in 1999. In 2003, the FDA approved Apydan as a monotherapy in children 4 years or older with partial epilepsy. This was the first epilepsy medication in 25 years to be approved for use as monotherapy in children.

Other names for this medication:
Oxcarbazepine, Trileptal, Actinum, Apydan, Auram, Aurene, Deprectal, Leptal, Oxcarbazepin, Oxcarbazepina, Oxetol, Oxicodal, Tolep,

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When the intracellular TCS concentrations in these cells were reduced by using a competitive inhibitor to block cell entry, cytotoxicity was not observed. These results suggest that patients with pathologic T1b-T2b cervix cancer with pelvic lymph node metastases are at high risk of recurrence or metastases after radical hysterectomy with pelvic lymphadenectomy and postoperative irradiation. Mean cotinine/creatinine levels showed a clear linear increase from the group of women not exposed either at home or at work, to the group of those exposed both at home and at work.

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Fifteen patients with IIM including eight patients with dermatomyositis (DM) and seven patients with polymyositis (PM) were studied. To evaluate the association between risk scores generated with a simplified method for periodontal risk assessment (Perio Risk), and tooth loss as well as bone loss during supportive periodontal therapy (SPT). The -344C allele of a 2-allele (C or T) polymorphism in the promoter of the gene encoding aldosterone synthase (CYP11B2) is associated with increased left ventricular size and mass and with decreased baroreflex sensitivity, known risk factors for morbidity and mortality associated with myocardial infarction (MI).

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Several approaches to treatment have been proposed, with a local injection of corticosteroids being the most frequently used. (iv) The spindle of asymmetrically dividing Nb is always oriented on an apical-basal axis. 4-Aminobenzoic acid hydrazide, a potent inhibitor of peroxidase activity of myeloperoxidase, produced no effect on neutrophil degranulation. Spontaneous respiratory modulation improves cardiovascular control in essential hypertension. Inhaled corticosteroids are the most effective agents for primary control of patients with persistent asthma.

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The increase in enzyme specific activity was directly proportional to hydrogen peroxide concentration up to 0.5 nM. Twenty percent of the patients subsequently developed AF, which allowed retrospective division of the samples into 2 groups, non-AF and AF. This article reviews advantages, limitations, controversies, and future directions in percutaneous image-guided core breast biopsy.

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The distribution of quantal content M is derived by ridge regression method from the distributions of sizes of the responses and of quantal sizes. We also pose questions whose answers we think are pivotal to understanding this path, and we provide answers where we can. The cannula consisted of silicone rubber tubing that was surgically inserted into the ductus deferens 10 to 12 cm from the end of the cauda epididymidis. To evaluate the effectiveness of two occupational health intervention programmes, both compared with usual care. US-Guided, Direct Puncture Retrograde Thoracic Duct Access, Lymphangiography, and Embolization: Feasibility and Efficacy.

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Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children. Dysfunctional apoptotic mechanisms are the pathologic basis for many human diseases, including common disorders of the heart, lungs, brain, and endocrine systems. Antibody dependant cellular cytotoxicity (ADCC) was performed in vitro using sera from immunized animals and immune individuals.

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alpha-Glucosidase I of Bacillus thermoamyloliquefaciens KP1071 (FERM P8477, facultative thermophile) was purified to homogeneity. Patients having hypercalcemia, abnormal renal function, myeloma and on long-term steroids were also excluded. Radiogenomics and imaging phenotypes in glioblastoma: novel observations and correlation with molecular characteristics.

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The levels of PON1 are similar in patients with and wthout prediabetes, but are significantly decreased in patients with insulin resistance and correlate with anthropometric markers of visceral adiposity. In the present study, we demonstrate the presence of hypoxia in normal developing embryos by means of a hypoxia marker, pimonidazole, and its associated antibody. The recombinant proinsulin has been isolated from the culture medium and its N-terminal sequence shown to be identical with that of natural human prohormone. Current clinical management with antimicrobials in periodontal patients We included 27 female nurses with a mean of 14.4 years of nursing experience.

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Neutrophils, lymphocytes, and dendritic cells (DCs) are part of this mucosal immune system. The participants were 318 mothers who participated in a physical examination of their four month old infants in Nagasaki City, Japan in 2003. This indicated further functional redundancy of sterol acylation in Arabidopsis.

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Moreover, the analytical approximations correctly describe the characteristic hyperbolic dependence of the erosion rate on enzyme concentration and the zero-order erosion of thin fibers. The right fractionation remains under discussion, but prostate cancer HDRB boost using a single fraction (providing similar results in terms of acute toxicity) is more comfortable for the patient, and less time consuming for the medical staff. cepacia) infection is rarely reported in an immunocompetent host. Effect of vaginal delivery on anal sphincter function in Asian primigravida: a prospective study. Geometric indexes of heart rate variability in obese and eutrophic children.

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Electrophysiologic evaluation of limb nerves and morphometric analysis of sural nerves obtained at biopsy were performed. The spatial resolution of the deprived eyes of monkeys lid sutured by 5 mo of age was about 6 octaves lower than normal values (Snellen acuities of about 20/2000). The outer domain epitopes include glycan-dependent epitopes (2 subjects), conserved nonlinear epitope in the V3 region (2 subjects), and a CD4BS epitope composed mainly of the elements in the outer domain (1 subject). Simultaneous ECoG and electrochemical recording supports the hypothesis that adenosine rises prior to seizure termination, suggesting that adenosine itself may be responsible for seizure termination. The purpose of this study was to assess patient-reported outcomes of breast reconstruction with implants, using the BREAST-Q, in the late postoperative period.

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variegatum, the highest photosynthesis rate (4.49 mmolm(-2)s(-1)) was recorded with benzyladenine concentration of 150 mg l(-1), and photosynthesis rate was found independent of watering frequency. The Pentacam measured significantly greater corneal curvature, thickness and elevation values compared to the Visante OMNI in normal and keratoconic eyes. A growing interest in developing orally active protein-kinase inhibitors has recently culminated in the approval of the first of these drugs for clinical use. We have investigated the growth-factor-like activity of a approximately 200-kDa, IP 8.3, cytoplasmic glycoprotein, the expression of which appears to be restricted to normal and malignant human mesothelium. The results suggest that dimensions of parenting are prospectively related to changes in CU traits.

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This report describes a successful pregnancy and delivery in a hypertensive woman with advanced chronic renal failure due to polycystic kidney disease without accelerating the natural deterioration of renal function and without instituting prophylactic dialysis. The objective of the study was the establishment of age- and sex-specific reference intervals for IGFBP-3 and the molar IGF-I to IGFBP-3 ratio by newly developed automated immunoassays. However, the quartz windows must be replaced after some time of operation. A cell survival assay of the four arabinosyl uridine analogs with functionalities of 5-fluoro, 5-fluorovinyl, 5-iodo, and 5-iodovinyl as potential positron-emitter tagged probe for monitoring cancer gene therapy were performed.

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The primary outcome measure was pathological complete response (pCR). anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model. Asp48 function in the hydrogen-bonding network involving Asp52 of hen egg-white lysozyme. The surgical treatment of many dentofacial deformities is often complex due to its three-dimensional nature. A locally funded Puerto Rican parrot (Amazona vittata) genome sequencing project increases avian data and advances young researcher education.

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The focus of this mini-review is to identify non-toxic compounds isolated from natural sources (plants) that exhibit specific activity against efflux pumps of specific multidrug-resistant (MDR) cancer cell lines, inhibit proliferation of the MDR cancer cell lines and inhibit the activity of overexpressed efflux pumps of the MDR cancer cell line. Completion or non-completion of courses of chemo- and radiotherapy, and reasons for non-completion were documented. Furthermore, this agent with its novel mechanism of action can be combined with standard therapies without a significant increase in toxicity. Some physicians remain unaware of the 2009 Korean treatment guidelines for CAP and do not use them in clinical practice.

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Most EB1-binding proteins contain a Ser-any residue-Ile-Pro (SxIP) motif. The patient was treated successfully with injection SAG 20 mg/kg parenterally for 60 days. RNA interference (RNAi) may overcome pesticide resistance by targeting the expression of genes that contribute to resistance in insects. The method was evaluated based on theoretical CT numbers for the reference human tissues.

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Here we identify clear differences in the mechanical responses of nanobubbles and nanodroplets under various modes of AFM imaging that subject the objects to predominantly vertical or lateral forces. Our aim in this project is to understand how age-related changes to neural structure and function interact to support cognitive abilities across the lifespan. VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels. We reconstructed and performed morphometric analysis on 43 AII amacrine cells, with a focus on branching pattern, dendritic lengths and diameters, surface area, and number and distribution of dendritic varicosities. Myocardial ischemia is double in patients with resting heart rate above 80 bpm, compared to those with heart rate below 60 bpm.

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In vitro cellular studies were performed using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS), fluorescence-activated cell sorting (FACS) and western blot analyses. Even after repeated injections (up to ten times) there was no evidence for decreased efficacy. Optimal stimulation during monitored thyroid surgery: EMG response characteristics in a porcine model. Respiratory illness after severe respiratory syncytial virus disease in infancy in The Gambia. The majority of these studies (20) assessed falls (including eight on hip fracture and four on multiple falls), eight studies reported traffic related injuries, and three studies assessed occupational injury.

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By immunofluorescence with monoclonal antibody, it was shown that wild-type HBsAg was distributed throughout the cytoplasm, whereas mutant HBsAg was concentrated around the nucleus, suggesting retention in the endoplasmic reticulum. During the latter part of zone II, AT-AR was nearly constant and AR-A remained nearly equal to A-A during the last 29 percent (mean value) of the cycle. A meta-analysis using Meta-Disc (version 1.4) and STATA software (version 13) was performed. The scatter of dose regimes found effective is too great to recommend a standardized approach to the prescription of L.A.P.

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Impact of endoscopic dacryocystorhinostomy on sinonasal quality of life. Major acute injuries are less frequently assessed in a standard rheumatological setting.Longitudinal studies are required to determine the clinical importance of US findings in athletes, particularly those who are asymptomatic. This case represents one of the unusual forms of metastatic invasion of renal cell cancer. Variability of attitudes toward early initiation of HAART for HIV infection: a study of French prescribing physicians.

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We encountered a terminal lung cancer patient with severe back pain and dyspnea who refused the use of morphine, and succeeded in home palliative care with the use of an original prescription (CA), the main ingredient of which was codeine phosphate. The most prominent biomarker is vascular endothelial-derived growth factor (VEGF).

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In the concrete case of a Floquet topological insulator, such a soliton forms when a wave packet induces, through nonlinearity, a defect region in a honeycomb lattice of helical optical waveguides, and at the same time the wave packet populates a continuously rotating outer (or inner) edge state of that region. Long-term Follow-up After Ileorectal Anastomosis for Ulcerative Colitis: A GETAID/GETAID Chirurgie Multicenter Retrospective Cohort of 343 Patients. Therefore, we performed a meta-analysis to better clarify the association between the promoter methylation of MGMT and HNSCC risk. Spontaneous fading of reticular pigmentation in Naegeli-Franceschetti-Jadassohn syndrome.

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The protein was run through poly acrylmide gel electrophoresis to view their protein profile. Motivated by this, and by dissatisfaction with the limited efficacy and tolerability of available anticancer modalities, a drug discovery programme was initiated with the aim of rationally developing targeted anticancer therapies.

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99mTc-HYNIC-D4 Peptide: A New Small Radiolabeled Peptide for Non Small Cell Lung Tumor Targeting. A xylanase gene (xynC) isolated from the anaerobic ruminal fungus Neocallimastix patriciarum was characterized. A cost-effective approach to simulation-based team training in obstetrics. In the present review the existing experimental data for vascular effects of estradiol metabolites are summarized.

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Contour interpolated radial basis functions with spline boundary correction for fast 3D reconstruction of the human articular cartilage from MR images. The prevalence of sporocysts/rediae and mean abundance of Echinostoma spp. Because of its ability to protect against placental infection, intrauterine fetal death, and maternal chronic Q fever, long-term cotrimoxazole treatment should be used to treat pregnant women with Q fever. The present study identified the activation of multiple and crucial angiogenic signaling pathways, which could function individually and/or synergistically to stimulate angiogenesis in HPC and eventually contribute to tumor growth and progression.

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In this article, we demonstrate the fabrication and detection of cancer protein biochips consisting of micro- and nanoarrays whereby pegylated quantum dots (QDs) conjugated to antibodies (Abs) of prostate specific antigens (PSA) were used for the detection of clinical biomarkers such as PSA. Associated relationships among demographic, health-related, social, economic factors and services of DS, including health demand (Type I), basic livelihood demand (Type II), and environmental support demand (Type III) were analyzed. The overall slower RT for children with SLI suggests that any deficit may be the result of processing deficits, perhaps attributable to interference effects. Some of these nerve processes showed local dilatations in contact with medullary cells and bone cells that were immunolabeled for synaptophysin, a nerve terminal marker.

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As statins have the anti-atherosclerotic pleiotropic effects, we retrospectively examined the effects of statins on restenosis after percutaneous coronary intervention (PCI). In the other three cases the diagnosis was made through ultrasounds explorations: It showed the mesenteric vein on the left side of the mesenteric artery. Furthermore, experimental arguments in favour of the existence of plant nitric oxide synthase (NOS)-like enzymes have been reported.

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Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling. Monitoring of intrathecal oxygen tension during experimental aortic occlusion predicts ultrastructural changes in the spinal cord. Finally, we found different levels of adaptation to the host genome within and between repABC operons coexisting in the same species. Conventionally measured TPMT activity is corrected for red blood cell (RBC) parameters.

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Stimulation by H2O2 showed a concentration- and time-dependent tyrosine phosphorylation of the proteins in rPLD1 immunoprecipitates and activation of PLD in the cells. Some of the discrepancies may be explained by methodological differences or biases. In this work, three iso-conversional methods (Friedman, Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS)) were compared with the Coats-Redfern method.

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Clinical and biological prognostic factors in relapsed acute myeloid leukemia patients Etiologies such as genetic causes, structural causes, chronic maternal disorders, drugs, environmental pollutants, endocrine causes, and immunologic causes are discussed, along with strategies for management. Results demonstrate a major contribution of ADC2 to total ADC activity and the specific induction of ADC1 in response to infection. The sampling network includes 31 moss samples evenly distributed over a territory of about 600 km(2). This study sought to obtain a precise profile of fluoride concentrations at and near the neonatal line in deciduous incisors and canines from the naturally fluoridated area (1.0--1.3 parts/10(6) F in drinking water) of West Hartlepool and the non-fluoridated area (less than 0.1 parts/10(6) F in drinking water) of Leeds in England.

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The oral cavity of the hospitalized or bedridden elderly is often a reservoir for opportunistic pathogens associated with respiratory diseases. The aim of the current investigation was to examine the association between naturally occurring variations in early life parental care and the cortisol awakening response (CAR), afternoon/evening cortisol output and key psychological variables in a sample of healthy young adults.

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We conducted a retrospective study in the Haematology Department of the University Hospital of Tours, France. The initiative sought to address poverty in a wide variety of ways, using minimal inputs. This comprehensive study provides insights into the biological functions of OsRFPs, which may be useful in understanding how rice plants adapt to unfavourable mechanism of action of phenytoin sodium injection environmental conditions. Conversion was deemed appropriate in 6 of 150 standard laparoscopies.

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There are several spectra methods can be used to detect abnormal radiation caused by manmade nuclides among a sequence of spectra. Search was faster and more accurate in the uncrossed condition, ruling out mediation either by V1-like tuned mechanisms or by a higher-level mechanism that signals differences in adverse side effects of trazodone in dogs orientation. The increased expression of CTGF suggests that CTGF plays an important role in the process of neural injury and fibrosis.

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To achieve single-mode propagation with low absorption loss, appropriate selection of the structural parameters for this kegunaan obat pumpitor 20 mg kind of waveguide is discussed. For latency scores grammatical class and imageability modified visual field differences: in the noun class a RVF advantage was obtained only for low imagery nouns, while for the verbs the RVF advantage was present for both medium and low imagery verbs. Comparison of the CoaguChek XS handheld coagulation analyzer and conventional laboratory methods measuring international normalised ratio (INR) values during the time to therapeutic range after mechanical valve surgery. Epigenetic abnormalities not only associated with carcinogenesis, they may also influence the curative effect and prognosis of anticancer drugs through modifying pharmacokinetic genes related to drug absorption, distribution, metabolism, excretion and pharmacodynamic genes related to signaling pathways and targets. Electron microscopy demonstrated the co-localization of PKC epsilon and integrin beta 1 on the vesicular membranes.

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When the need for reaction is high, it is accompanied by strong changes in cell organization and composition called reaction wood, namely compression wood in gymnosperms and tension wood in angiosperms. Fatigue of the resin-enamel bonded interface and the mechanisms of failure. OA of the hip joint (hip OA) in Japanese patients is associated with a high incidence metrin scientific skincare reviews of degenerative lumbar spondylolisthesis (DS). If changes in route are seen in individuals or within populations, then study of these transitions in route may identify new approaches which could be developed in HIV prevention.

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Interferon-gamma mRNA expression upon in vitro T lymphocyte activation is decreased in rheumatoid arthritis patients. Cystoscopic examination demonstrated no abnormality, except omeprazole 40 mg po bid ac for bloody urine efflux from the right ureteric orifice.

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Old mice with cardiac-specific overexpression of constitutively active V12Rac1 (RacET) were compared oxytetracycline hydrochloride tablet 50 with wild-type (WT) and WT undergoing transaortic constriction (TAC). However, the question is which participants should be involved and how. This paper examines mapping and related data-gathering at geographical locations of vulnerable urban groups with regard to risky sexual behaviors and alcohol/drug use in the capital city of Delhi. Our limited experience demonstrates that a hybrid procedure is a viable and relatively safe treatment strategy for patients with TBAD and an ARSA. If toxoplasma manipulates emotional valence of cat odor rather than just sensory response, infection should affect learning driven by the aversive properties of the odor.

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MS has been widely coupled with chromatographic techniques, both gas chromatography (GC) and liquid chromatography (LC), because of their complementary nature when facing a broad range of organic pollutants of different polarity and volatility. Genetic diversity of mitochondrial cytochrome daktarin gel buccal pour nourrisson allaitement b gene in Chinese native buffalo. helped to define the origin of green pythons (Morelia viridis) confiscated in Germany.

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TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells. With adequate clinical support, application of this pathway allows decisions to be made on hospital discharge following the clinical criteria of improvement without worsening prognosis. Furthermore, we show how these GABA receptors modulate the time course of innate trichomoniasis treatment metronidazole dosage for puppies behavioral responses after odor pulse termination, demonstrating an important role for temporal contrast enhancement in odor-guided navigation. Outcome of fetal cystic hygroma and experience of intrauterine treatment. Cell apoptosis was determined by ELISA and real-time PCR assays.

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Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a citalopram and alcohol hangover treatments literature review. In addition, we introduce a new approach to measuring hierarchy between drug targets, somatic mutants, and disease susceptibility genes by utilizing directionality and path length information. In this study we sought to explore the relationship between cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) and histopathological parameters including interstitial fibrosis and replacement fibrosis (scar) in patients with hypertrophic cardiomyopathy (HCM).

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Schistosomiasis in the Republic of Guinea (its territorial districting) In the trokendi clopidogrel 75mg prices current study, we attempted to further explore the effects of myostatin on adipocytes and its potential to reduce fat mass, since myostatin administration could potentially be a useful strategy to treat obesity and its complications in humans. The unified scheme of the total operating process has been built allowing the evaluation of working conditions and radiation doses for personnel at every operating stage, some experimental results are given. Subjects were classified into one of these blood-pressure categories: 1-optimal, 2-normal, 3-high-normal, 4-grade 1 hypertension, 5-grade 2 hypertension and 6-grade 3 hypertension.

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