Apydan is a homologue of the well-known antiepileptic drug carbamazepine. It was developed as an alternative to carbamazepine for patients who had adverse reaction to carbamazepine or diphenylhydantoin. Despite its structural similarities, Apydan differs from carbamazepine in pharmacokinetic behavior, biotransformation profile, and interaction potential. Apydan is like carbamazepine in its mechanisms of action and antiepileptic efficacy but has better tolerability and fewer interactions with other drugs. Most of the clinical development took place during the early 1990s, when it received approval in several countries. It was approved by the FDA in 1999. In 2003, the FDA approved Apydan as a monotherapy in children 4 years or older with partial epilepsy. This was the first epilepsy medication in 25 years to be approved for use as monotherapy in children.
Other names for this medication:
Oxcarbazepine,
Trileptal,
Actinum,
Apydan,
Auram,
Aurene,
Deprectal,
Leptal,
Oxcarbazepin,
Oxcarbazepina,
Oxetol,
Oxicodal,
Tolep,
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