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Protein remote homology detection based on bidirectional long short-term memory. Based on our results, most patients presenting with this common problem are not receiving optimal initial management or advice prior to otolaryngology referral. Pseudomonal infections of the skin, soft tissue, bone, and toe web may often be very difficult to treat. The internal mechanical properties of cervical intervertebral discs as revealed by stress profilometry. Though usually considered ER-negative, this cell line displayed basal significant estrogen binding capacity and co-expression of both ER isoforms.

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The combination of bedside swallowing assessment and oxygen saturation monitoring of swallowing in acute stroke: a safe and humane screening tool. Recommendations for improving this situation include the adoption of organizational models that provide periods of mentoring from colleagues already in the company and the assignment to simple and not much hazardous tasks.

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Furthermore, there was a significant increase in TGF-beta1 expression in the prostates of patients treated with terazosin or combination therapy, while there was no change in TbetaRII expression. Poisson regression models with robust variance were used to evaluate the association between age at menarche and NAFLD.

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Transcription, translation and copy number of mitochondrial DNA. The present work has been undertaken in two steps to study the uptake and the intracellular processing of pDNA, which are still poorly understood in the polyfection pathway. Bronchoalveolar lavage (BAL) has become an established method for the diagnosis of infectious and interstitial lung diseases.

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Further trials are needed with rigorous methodology and sufficient statistical power. Both extent of cake collapse and storage temperature affected the physical stability of the shake-stressed lyophilized mAb upon subsequent storage. The radiation dose with the posterior-anterior SPR was higher, because the divergence of the X-ray beam magnifies the anatomical structures closest to the tube, especially the spinal column, and this leads the ATCM system to estimate higher patient attenuation values and, therefore, to select higher tube current values.

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However, the prognosis of T-cell lymphoma remains poorer than that of B-cell lymphomas, and progress is slow. TDP-43 globular glial inclusions (GGI) were identified in one case. We observed that the on-site checklist was highly time-consuming but could be tailored to capture frequent problems.

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Anthocyanin appeared in all organs of the seedling.Wounding of the plant led to an increase in the content of anthocyanin due to increased anthocyanin synthesis in the cotyledons.The action spectra of anthocyanin formation in tissue cultures and intact seedlings have two peaks, one at 438 nm and the other at 372 nm. L-2-Hydroxyglutaric aciduria (LHGA) is a rare autosomal recessively inherited neurodegenerative disorder. Blinded off-line analysis correlated microembolic signal counts on TCD with the components of each stage of the PTCA.

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However, complete responses are rare and therapy is not curative. In patients with no risk factors for liver disease, with normal physical examination and liver tests, biopsy can be done after a cumulative MTX dosage of approximately 1 to 1.5 g and repeated for each gram.

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This paper describes the successful implementation of a dedicated fibre optic network for the real time stereo video imaging. The minimum-energy broadcast problem is then equivalent to the problem of finding the minimum Connected Dominating Set (CDS) for a connected graph that is proved NP-complete. Behavior in vitro of the dentin-enamel junction in human premolars submitted to high temperatures: prediction of the maximum temperature based on logistic regression analysis. Microarray-based comparative genomic hybridization (array-CGH) has emerged as a revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations.

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Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. The animals in the experimental groups were systemically treated post-operatively with estrogen-progesterone, methylprednisolone-acetate (Depomedrone) or cis-hydroxyproline. These results indicate that there are major disparities in the localization of the alpha-bungarotoxin-binding alpha 7 and alpha 8 nAChR subunits and the beta 2 structural nAChR subunit in the chick diencephalon and mesencephalon.

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Fluorescent proteins serve as important biomarkers for visualizing both subcellular organelles in living cells and structural and functional details in large-volume tissues or organs. Surveys of published papers show that there are many errors both in the design of the experiments and in the statistical analysis of the resulting data.

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In this study, we evaluated EGFRvIII expression in pediatric DIPG samples using immunohistochemistry with a double affinity purified antibody raised against the EGFRvIII peptide. Tissue engineering vascular grafts a fortiori: looking back and going forward. More importantly, recent advances in regenerative medicine demonstrate that bioactive hydrogels can be properly designed to induce at least partial skin regeneration in vivo. Carcinogenicity of the antineoplastic agent, 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide, and its metabolites in rats. Prenatal alcohol exposure alters response of kisspeptin-ir neurons to estradiol and progesterone in adult female rats.

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Metals in neurobiology: probing their chemistry and biology with molecular imaging. Using this method, we demonstrate label-free 3-D imaging of live RKO human colon cancer cells and RPMI8226 multiple myeloma cells, and obtain the volume, dry mass and density of these cells from the measured 3-D refractive index maps. In vivo magnetic resonance imaging of sodium and diffusion in rat glioma at 21.1 T. The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase. Thus, the objective of this study is to identify the origin of Fe and Mn contamination in groundwater and the hydrogeochemical processes that can enrich aquifers with these metals.

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Little is known, however, whether obsessive-compulsive comorbidity entails particular effects. Dyslipidemia in subclinical hypothyroidism and the effect of thyroxine on lipid profile. Wrong-level spine surgery is defined as a never event by Center for Medicare Services, yet the strength of data supporting the implementation of Universal Protocol to limit wrong level surgery is weak. light scatter was determined with a straylight measuring device, whereas light transmission was measured using a broadband absorption spectrometer.

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Here, we have reported a primary seminal vesicle adenocarcinoma with hepatic metastases, managed with multiagent chemotherapy (oxaliplatin and 5-fluorouracil based) and androgen ablation (with triptorelin). Hydrodynamic and functional analysis of HIV-1 Vif oligomerization. A variety of single unit and local field potential signals were recorded from the dorsal striatum and substantia nigra in mice and the ventral striatum and prefrontal cortex simultaneously in rats. Parasitic diseases, such as African sleeping sickness, have a significant impact on the health and well-being in the poorest regions of the world. These data suggest that Rap1GAP acts as a signal integrator to somehow coordinate and/or integrate G(z) signaling and Rap1 signaling in cells.

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However, there are differences in costs and priority for reproduction among species and even between sexes, which leads to diversification of interactions between reproduction and nutritional status. It was found that perfusion of the isolated rat liver with the TC-199 Difco medium containing the perfluoro-compound FC-80 emulsion maintained the liver in a good condition demonstrated, among other things, by the synthesis of albumin and other proteins.

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Take-home naloxone for treatment of opioid emergencies is now being recommended by numerous federal, state, and professional organizations. Patellofemoral arthritis treated with resurfacing implant: Clinical outcome and complications at a minimum two-year follow-up. Further Light on the Mechanism of Sandfly Transmission of Kala-Azar.

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ROS-induced primary stimuli result in the increased secretion of proinflammatory cytokines and other mediators, promoting events that appear to be important in the progression of cell injury and pulmonary disease. Herein, we report a new and efficient full-spectrum-responsive photocatalyst composed of Bi2S3 nanotubes incorporated with carbon quantum dots (C-dots) for rapidly degrading methylene blue (MB) and tetracycline hydrochloride (TC). Finally, the isodiffusivity lines show that in this system with short-range attractions, there is no reentrant glass phenomenon as opposed to monocomponent attractive systems. To assess if futile cycling of ketoprofen occurs in patients with decreased renal function. Alternative intraperitoneal chemotherapy regimens for optimally debulked ovarian cancer.

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However, progress does not imply that third-party reimbursement is uniform nationwide or effortlessly achieved. Photodynamic inactivation (PDI) is a rapidly developing antimicrobial technology in which a non-toxic photoactivatable dye or photosensitizer is excited with harmless visible light to its reactive state, where it will generate highly toxic reactive oxygen species. Cellular microbiology is a newly developing science born from the realization that many different aspects of eukaryotic cell biology are targeted by microbial virulence mechanisms.

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Different molecular conformations co-exist in each of three 2-aryl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamides: hydrogen bonding in zero, one and two dimensions. This prospective study evaluated the association of obesity and hypertension with left atrial (LA) volume over 10 years. In absence of cAMP, the repair of the PEPCK fragment was similar in cultured hepatocytes isolated from young and old rats fed ad libitum.

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Differential effects of a gram-negative and a gram-positive infection on autogenous and prosthetic grafts. Chromatin is a dynamic DNA scaffold structure that responds to a variety of external and internal stimuli to regulate the fundamental biological processes. This case presents the rare occurrence and management of late postoperative complications of backward implantation of a Vivarte pIOL. Thus, it is urgent to identify a tumor marker or a molecular target that allows early detection and effective treatment. Surgical resection plus topical interferon alpha-2B might reduce the risk for recurrence or new tumor.

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The vaccine has now been administered to more than 6000 children and adults from dengue endemic and non-endemic areas and no safety concerns have arisen in any of the completed or ongoing trials. The effect of including a pH-sensitive endosomolytic peptide on the physicochemical properties of the complex was determined.

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CPE was reported to improve immune function against microorganisms, but the mechanism is unknown. Excluding corneal epithelial toxicity that was more common with 5-fluorouracil, the two agents used had similar success and complications during the short followup period.

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Hyperviscosity might possibly serve as an additional parameter to characterize chronic progressive hepatitis and to indicate steroid treatment. We demonstrate that human ESCs originate from a post-ICM intermediate (PICMI), a transient epiblast-like structure that has undergone X-inactivation in female cells and is both necessary and sufficient for ESC derivation. 3-(4,5-dimethylthiazole-2-yl)-2.5-dipheny-ltetrazolium bromide (MTT) assay was used to detect the effect of AMD3100 on cell proliferation. Cell apoptosis was assessed by Hoechst 33258 staining and flow cytometry.

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Pleckstrin homology (PH) domains have been identified only in eukaryotic proteins to date. We investigated the relationship between season of birth and the Junior Temperament and Character Inventory of Personality (Junior TCI, JTCI) in adolescents. Calcium- and voltage-dependent potassium channel in the rat retinal amacrine cells identified in vitro using a cell type-specific monoclonal antibody. The activity of the enzyme is highest in cells grown on lactate or glucose and virtually absent in cells grown on malate or aspartate. The introduction of auditory stimulation with a CI can not restore the loss of neural plasticity out of this period.

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A number of oxalamide derivatives have been synthesized and evaluated for PAI-1 inhibitory activity. The properties of single-crystal SrTiO3 substrates and homoepitaxial SrTiO3 films grown by pulsed laser deposition have been compared, in order to understand the loss of interfacial conductivity when more than a critical thickness of nominally homoepitaxial SrTiO3 is inserted between a LaAlO3 film and a SrTiO3 substrate.

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Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase. Perceptions and practices of a pakistani population regarding cervical cancer screening. Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation. Generating health technology assessment evidence for rare diseases.

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As both CBT approaches involve strengths and limitations, a hybrid form of treatment is needed that simultaneously addresses pain and sleep. The large green/red ratio indicates that the source is not associated with the Venus ionosphere. Moreover it must be borne in mind that limited long-term efficacy and safety data are available and that adherence of patients to DOACs may be a major issue in the real-life setting.

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Diversities in the clinical condition of psoriasis patients due to increasing type D personality traits are specified. Ultrastructure was visualised using Scanning Electron Microscopy.

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Seasonal dynamics with compensatory effects regulate populations of tropical forest marsupials: a 16-year study. Serum cystatin C measured by a sol particle homogeneous immunoassay can accurately detect early impairment of renal function. Five guaianolides and a germacrolide were isolated from the leaf rinse extract of Viguiera gardneri (Asteraceae), together with known compounds. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. From age 10 years 5 months, 4 months after onset, EEG disclosed progressive deterioration of background activity and incremental increase in epileptic discharges.

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Screening for functional kinases in metastatic prostate cancer: a glimmer of hope for kinase inhibition. Eight hundred and fourteen patients with a diagnosis of hilar cholangiocarcinoma that were evaluated and treated between 1990 and 2014, of which 381 patients underwent curative surgery, were included in this study. Transient microfluidic compartmentalization using actionable microfilaments for biochemical assays, cell culture and organs-on-chip. Efforts are being directed toward decreasing the number of these procedures, in part by encouraging physicians to make changes in their management practices. Previously, we have identified a transcription initiation site (for mRNA 2-1), which is more efficiently transcribed by viruses containing two copies of UCUAA sequence in the leader RNA than by those with three copies.

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In addition, inter- and intra-observation reliabilities of basic cardiac views using 3D ultrasound were evaluated for their clinical applicability. Longer Time to Treatment Entry was predictive of longer time to relapse. Outcome differences have been found in patients with Mucor and Aspergillus.

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Systematic review and meta-analysis of reports published between 1959 and 2013. We demonstrate that Branchless (Bnl), the fibroblast growth factor ligand, regulates restructuring events in the eye disc primordium from as early as the emergence of clusters from a morphogenetic front to the cellular movements during pupal eye development.

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Chronic intoxication often poses a diagnostic dilemma with atypical presentations mimicking other disease states such as diabetic ketoacidosis, delirium, cerebrovascular accident, myocardial infarction or cardiac failure. Previous self-motion research using virtual environments has primarily considered the properties of diffuse optic flow, but not of specular flow. The concentration of preoperative serum PSA showed a significant correlation with the prostatic volume and with the transition zone volume. Influence of latent iron deficiency on generation of oxygen species in polymorphonuclear leucocytes.

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The determination of cutaneous cholesterol is of clinical interest, because of its correlation with the degree of atherosclerosis. We developed and evaluated a new method to automatically measure regional left ventricular wall thickening by analyzing the radiofrequency backscatter signal from an intracardiac echocardiographic catheter. A reduction in the total amount of medication is seen between admission and death in the palliative care facilities.

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There are major content differences among analyzed questionnaires. N-Bromosuccinimide cleaves F1-histone into two fragments, a small N-terminal piece and a larger C-terminal portion. Cerebral metastasis of small-cell lung carcinoma mimicking a supratentorial cystic astrocytoma. Role of rifampin-based combination therapy for severe community-acquired Legionella pneumophila pneumonia. To determine the correlation between the duration of macular edema (ME) and visual outcomes among Korean patients with retinal vein occlusion (RVO).

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Research that has explored the properties of the face-space and sought to understand caricature, including facial adaptation paradigms, is reviewed. Chronic rhinosinusitis with nasal polyps is associated with chronic otitis media in the elderly. Analysis of the genome sequence has provided important insights into the DNA repair machinery of the pathogen, and the studies on DNA repair in mycobacteria have gained momentum in the past few years. The first phase of data collection was conducted in the hospital with mothers after the delivery. Despite modern surgical and intensive-care concepts, diffuse peritonitis remains a major source of high morbidity and mortality.