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Cobese (Orlistat)
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Orlistat

Cobese is a gastrointestinal lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats. Cobese is a white to off-white crystalline powder. Cobese is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Cobese has no pK within the physiological pH range.

Other names for this medication:
Orlistat, Cobese, Ishape, Lipocut, Lipophage, Obelit, Obezita, Oristal, Orlica, Reeshape, Vyfat, Xenical,

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Use of the new contact force sensing ablation catheter dramatically reduces fluoroscopy time during atrial fibrillation ablation procedures. Descriptive statistics assessed work organization variables, sleep duration and quality, and frequency of engaging in safety-relevant performance while sleepy. The oxygenation of different types of biological membranes (rat liver mitochondria, rat liver endoplasmic membranes, inside-out erythrocyte ghosts, right side-out erythrocyte ghosts) was studied with respect to products formed during the reaction. Biceps muscles of hatched chicks, in which muscle of the donor was innervated by nerves of the host, were analyzed for embryonic properties of muscle acetylcholinesterase and for fiber diameter, two distinctive markers for expression of the dystrophic gene. If these reponses have cytotoxic or other protective functions, they may help overcome the suboptimal heterologous protection conferred by conventional vaccines.

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The intervention provided that most scarce of caregiver commodities--time. This article focuses on my interpretation of the history of ethnic minority psychology, using as a base the presentations of the contributing authors to this special issue of Cultural Diversity and Ethnic Minority Psychology.

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Labeled cells were counted in the spinal cord, brainstem, hypothalamus, and thalamus. Boilerplated content is the source of challenges for concept extraction on clinical text.

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This procedure was paired with positive reinforcement and escape prevention to increase oral consumption of liquids and solids. A 48-year-old man who had been experiencing aggravation of dyspnea for several months was diagnosed as having ACC of the trachea on the basis of a pathologic examination of a biopsy specimen obtained via laser microscopy-guided resection. Besides, CD81 was found to be up-regulated, suggesting a possible role in the internalization of the virus. In the present study we reported an integrated proteomics, phosphoproteomics and metabolomics overview of meat tenderness in longissimus dorsi from 15 male Maremmana individuals, through the discrimination of tender and tough groups via standard meat tenderness indicators (WBS, MFI(4 h), MFI(10 days), sarcomere length) and their correlation with results from Omics analyses. Measuring the volume of a cystic hygroma proves to be a useful ultrasound prognostic indicator in determining the risk of an associated karyotypic abnormality and adverse fetal and pregnancy outcome.

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This paper discusses the evolution of the genes and regulatory mechanisms that helped drive such significant morphological innovations among land-based plants. Among them, only 2 had been electively operated and both successful. Questions in multiple choice format were in English and it was a self-administered questionnaire consisting of three parts (knowledge, attitude, behavior). Urinary sediment examination and urine cytology revealed malignant melanoma cells. Two and four mini dental implants can be immediately used successfully for retaining lower complete dentures, as shown after a 1-year follow up.

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The cause was an insect determined as Sclerodermus domesticus, known for its parasitism on larvae of a wood pest. But, when probe direction matched the ignored prime direction, sensitivity was enhanced, even though both components were of equal physical strength. The cod-tools package has been successfully used for continuous updates of the data in the automated COD data deposition pipeline, and to check the validity of COD data against the IUCr data validation guidelines.

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Establishing whether the structural feature controlling the mechanical properties of starch films is molecular or crystalline. EAT thickness correlated with (123)I-MIBG early and late heart:mediastinum ratio and single-photon emission computed tomography total defect score, but not with left ventricular ejection fraction. Knowledge of the characteristics of these patients can assist policy makers in developing measures to retain them in care. Mefenamic acid (Ponstan)-induced acute interstitial nephritis with reversible, severe, non-oliguric renal failure

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3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been associated with improved clinical outcomes after ischemic stroke and subarachnoid hemorrhage, but with an increased risk of incidental spontaneous intracerebral hemorrhage (ICH). Interconversion between different nuclear spin species of SiH(4) is found to be absent during the jet expansion. Myocardial fibrosis, apoptosis, progressive LV dilatation, and eventually LV dysfunction are seen with the progression of disease. The CI provided positive support in the professional sphere as well as in social abilities by improving communication skills of implanted patients.

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Poxvirus-encoded vPOPs represent a novel class of immune evasive proteins and impair the host response by blocking Cryopyrin and ASC inflammasome-mediated activation of pro-Caspase-1 and subsequent processing of pro-interleukin (IL)-1beta, and expression of vPOPs causes activation of NF-kappaB. Expression characteristics of the Ccdc70 gene in the mouse testis during spermatogenesis The addition of local anaesthetics for continuous low-flow infusion of opiates requires further comparative studies. These ligand-sensing ncRNA regulators provide useful tools to modulate the activity of structurally related families of ncRNAs, and building upon the growing body of RNA synthetic biology, our ability to design aptamer-ncRNA fusion molecules offers new ways to engineer ligand-sensing regulatory circuits. Experiments were performed with a known volume of the liquid and at varying rotation rates such that the inertial effects were negligible.

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Silymarin, a lipophilic extract derived from milk thistle (Silybum marianum) has been used in liver and bile disorders for centuries. A retrospective, descriptive, and comparative study design was used.

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These results add to the increasing evidence for diversity among E. Down-regulation of atopic dermatitis-associated serum chemokines by wet-wrap treatment: a pilot study.

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Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system. The role of vitamin D analogs are reviewed with emphasis on the comparison between calcitriol and paricalcitol. Further studies are needed to establish inter-rater and intra-rater reliability. We sequentially applied two established incidental learning tasks differing in stimuli, responses and hidden regularity (the alphabet verification task followed by the serial reaction task, SRT). In the majority of the patients reported, a mutation of the gene that encodes the pantothenate kinase (PANK2) located in the 20p13-p12.3 chromosome that causes iron storage in the basal ganglia of the brain has been found.

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Strategies to optimise management and avoid hospitalisation, where possible, are needed. The Santa Cruz information exchange experience offers lessons on what works. However, prevention of ascorbate loss and hydrogen peroxide formation in any multivitamin solution requires protection of the delivery system from light. For each item, a binary score (present/absent) and a precision score were used.

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Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons. Respiratory motion compensation by model-based catheter tracking during EP procedures. Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study. Immunoblotting showed that the recombinant DGAT1 (rDGAT1) was expressed, but mostly targeted to the membranes and insoluble fractions.

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Similar effects were observed in one of the conditions of a mental rotation task. The purpose of our study was to examine the accuracy of short-interval follow-up mammograms and evaluate patient and radiologist characteristics associated with accuracy. We conducted cross-sectional and prospective analyses of existing data from 761 VA PC patients with probable major depression.

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Antioxidant defense mechanisms and the toxicity of fibrous and nonfibrous particles. Counting, starting with finger sequencing, has been observed in different ancient and contemporary cultures, whereas number representation and arithmetic abilities are found only during the last 5000-6000 years. There were 43 differentially expressed sRNA candidates, including 28 up-regulated and 15 down-regulated ones. Comparative studies between cefixime and conventional antibiotics for the treatment of upper respiratory tract infections and otitis media are summarized.

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CGRP-positive fibers closely interacted with grafted ependymal cells. We compared the 2012 recommendations and the arguments of the IAS-USA Panel with the data referenced and presented with the original data of the studies. Midwives and postabortion care: experiences, opinions, and attitudes among participants at the 25th Triennial Congress of the International Confederation of Midwives. In this study, we aimed to evaluate sensitivity and specificity of the Basophil Activation Test (BAT) as a diagnostic and monitoring test in patients with mastocytosis and WVA.

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The geometric mean value of indoor to outdoor ambient dose equivalent rates was found to be 0.88, i.e. Of 56 subjects with a history of alcohol and/or drug abuse, an early onset was ascertained in 31. The analyzed TPS presented good results, but for some particular clinical cases and moreover for advanced techniques such as intensity modulated radiation therapy, the calculation behaviour with respect to measurements and patient dose delivery should be carefully evaluated. Here, we review progress in stem rust pathogenomics and approaches currently underway to identify Avr genes recognized by wheat Sr genes. We evaluated the cell killing effect of combined rapamycin and cisplatin treatment and showed that the combination had a more than additive effect in both androgen dependent and independent prostate cancer cells, which may be partially explained by the reduction of cyclin D1 expression by rapamycin.

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When grown in vitamin B12-deficient medium, the mutant strain showed a four-fold increase in its doubling time compared with that of the wild-type strain, and this effect was counteracted by supplementing the medium with vitamin B12. Surgical tracheostomy was performed while she was mechanically ventilated through the tracheal esophageal combitube. Therefore, several healthcare systems have introduced minimal numbers per hospital to centralize certain procedures. In extensive numerical simulations of pulsed PTR temperature profiling in human skin using three common IR radiation detectors and several acquisition spectral bands, we demonstrate that our approach produces viable values micro(eff). Ultrastructural study of hepatitis B virus in biliary epithelial cells of duck liver.

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Because little is known of the three-dimensional shape and volume of the abrasion caused by different powders, it is the aim of the study to investigate the three-dimensional extent of these defects. The purpose of this paper is to examine the Maris hypothesis that some people have relevant biographies and life histories that predispose suicidal careers.

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These results suggest that PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. Toxic hepatitis and hematologic disorder in a work environment: A case report. These findings implicate androgen-induced TOP2B-mediated DSBs in generating TMPRSS2-ERG rearrangements. Two-stage carcinogenesis experiments on mouse skin (female ICR/Ha Swiss mice) were done by initiating mice at three age levels (6, 44, and 56 weeks) and promoting after a 2-week interval. Solubility and dissolution performances of spray-dried solid dispersion of Efavirenz in Soluplus.

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Bcgr (C.D2) mice, unlike their congenic strain BALB/c, restricted bacterial growth following the intravenous inoculation of 2.5 x 10(8) CFU of M. Because we expected G6PT-deficient neutrophils to be unable to produce endogenous glucose, we hypothesized this would lead to ER stress and increased apoptosis. Ultrasound as a primary evaluation tool of bone stress injuries in elite track and field athletes. Acute osteomyelitis is usually acquired hematogenously, and the most common pathogen is Staphylococcus aureus. We describe a new retroviral insertion site that is the most frequent genetic alteration in AKXD B-cell leukemias.

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However, certain patient populations have been excluded from these landmark clinical trials, including patients with renal insufficiency, obese patients and pregnant women. Furthermore, an isoelectric focusing method for the separation of isoenzymes was developed. Although an immunoassay solid phase prepared with ladybug whole body extract will identify persons in a general population sensitized to epitopes found in the extract, clinicians performing allergy testing using whole body ladybug extract should be aware that a positive result may or may not indicate that exposure to actual ladybug allergens is causing sensitization. We conducted a literature search (Medline, 1984-1999) for intervention studies (at least 2 months in duration) that have examined the independent effect of either REX or AEX on body composition in older individuals. Estimation of cerebral surface area using vertical sectioning and magnetic resonance imaging: a stereological study.

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In an in vitro study of 100 patients with primary open-angle glaucoma and various degrees of ocular pressure responsiveness to corticosteroid testing, varying degrees of sensitivity to corticosteroid compounds existed systemically in the circulating lymphocyte. The tumor microenvironment plays a major role in tumor growth and progression. Suppression of cytotoxicity, measured after 4 days of LAK generation, could also be demonstrated when the conditioned tumor supernatant was present in only the last 24 hours of incubation.

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One of the requirements of a Global Fund grant is the regular and accurate reporting of program outcomes and impact. This study was implemented in laboratories from three hospitals in different provinces of Angola: Bengo, Benguela and Luanda. Here we have identified a cellular signaling pathway in alveolar macrophages and other phagocytes that is specifically activated by flagellar motility. A comparative numerical and experimental study shows the efficiency of this element. We propose that in the absence of regulatory light chain phosphorylation, the two heads of myosin interact with each other, due to a weak intrinsic dimerization of the regulatory domains that is significantly stabilized by the proximal rod.

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To determine whether a neutralizing antibody against DEN in vitro was also protective in vivo, the K562-SCID mice were challenged with DEN-2 and received antibody administration at the same time or 1 day earlier. This is a retrospective study of 82 patients presented at NCI, Cairo University with salivary gland lesion who underwent preoperative FNAC diagnosis with subsequent excision and histopathologic assessment. Furthermore, antigen-specific IgA was detected in the lung, and an IFN-gamma response was observed upon re-stimulation with antigen.

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Measuring the velocity of fluorescently labelled red blood cells with a keyhole tracking algorithm. We evaluated neurohormonal and renal responses of Wistar rats to chronic oral administration of 20 and 100 mg/kg per day NG-nitro-L-arginine methyl ester (L-NAME). Until now no accepted method exists to achieve accurate fine-tuning: i.e. The different activities of arginase, arginine synthetase, ornithine transcarbamoylase and delta-ornithine transaminase in the liver and blood cells of some farm animals.

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This is a case report of a 37-year-old female with a uterine septum (two cavities), a normal single fundal contour, two cervices, and a longitudinal vaginal septum. Products of animal-origin enriched with n-3 LCPUFAs can be a good example of functional food, that is food that besides traditionally understood nutritional value may have a beneficial influence on the metabolism and health of consumers, thus reducing the risk of various lifestyle diseases such as atherosclerosis and coronary artery disease. Eight new sequences of European isolates from almond, apple, hop, prune and pear of the Apple mosaic ilarvirus (ApMV) capsid protein gene are presented. The results show that ingestion of a phosphine-fumigated diet by the rat for 2 yr does not cause any marked modification of growth, food intake, nitrogen balance, body composition, functional behaviour or the incidence or type of tumours. However, at higher energies there are deviations from the predictions of this model.

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Chicken (Gallus gallus) is an important model organism for developmental biology, and the recently assembled genome sequences for chicken will facilitate the understanding of the functional roles of non-coding RNA genes during development. Sarcoidosis is a multisystemic inflammatory disease with myriad clinical manifestations. Lymphocytes stimulated with supraoptimal concentrations (5-20 micrograms/ml) of PHA showed slightly less iron uptake from 59Fe-Tf and had a longer transferrin cycle time, as compared with the cells under optimal stimulation. The patients with systemic connective tissue diseases and HV were found to have prognostically poor types of 24-hour BP profile (night-peaker, non-dipper), the magnitude of which elevation depended on renal function and plasma renin activity. Antibodies produced by GI recognized human and mouse sperm acrosin systems, inhibited human proacrosin/acrosin interaction with recombinant human ZPA and protease activity, and negatively affected mouse IVF and early embryonic development.

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Preoperative rise in CEA, lymph node metastasis, multiple lesions and extrahepatic invasion are significant adverse prognostic factors for patients with intrahepatic cholangiocarcinoma after surgical resection. Cytological findings of the pleural effusion included many atypical lymphocytes. Three RNA editing events are observed in the split group II intron sequences. The diameter of AAA is a surrogate marker of its growth rate that reflects the magnitude of the degenerative process in the vascular wall, although most AAAs show discontinuous growth patterns and alternate periods of stability and nongrowth with periods of acute expansion and occasionally ruptures.

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Patients at the anticoagulation clinic were recruited between August and October 2011, with minimum follow-up of four weeks. To evaluate the effectiveness of intrauterine balloon tamponade (IUBT) for management of severe postpartum haemorrhage (PPH). We evaluated the retinal toxicity of antimicrobials (sulbenicillin, cefazolin, flomoxef, gentamicin, sisomicin, netilmicin, tobramycin, amikacin, vancomycin, ofloxacin, lomefloxacin, and miconazole) by the electroretinogram, before and after a single-shot intravitreal injection in rabbits. Alternatively, migration, as an adaptive strategy of last resort, might be delayed and employed only after available in-situ (in-place) adaptive strategies are exhausted.

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This study sought to perform cloning and sequencing of the dihydrofolate reductase ( dhfr ) and dihydropteroate-synthase ( dhps ) genes of the reference Rh strain and two Colombian isolates of Toxoplasma gondii . The C4 forms result from convergent evolution in multiple clades, with substitutions at a small number of sites under positive selection.

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