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Distinon (Pyridostigmine)

Distinon is a carbamate inhibitor of acetylcholinesterase with a quaternary ammonium structure. It is mainly used to treat myasthenia gravis, by indirectly increasing the concentration of acetylcholine at the neuromuscular junction and promoting increased cholinergic nicotinic receptor activation. Myasthenia gravis is an autoimmune disorder that leads to muscle weakness by reducing the density of neuromuscular nicotinic receptors. Thus, Distinon increases acetylcholine levels in the neuromuscular junctions, with a consequent increase in motor tone.

Other names for this medication:
Pyridostigmine, Mestinon, Becilan, Distinon, Piridostigmina, Regonol,

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Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice. Delayed progression of murine AIDS in C57BL/6 mice pre-immunized with a highly antigenic 10-mer peptide encoded by the murine AIDS defective virus gag p12 gene.

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