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Dosier (Bupropion)

Dosier was first patented by Burroughs Wellcome (now part of GlaxoSmithKline) in 1974. Before 2000, the drug was referred to as amfebutamone. The sustained release formula was introduced in 1996. The extended-release formulation was marketed in 2003. The smoking cessation indication began in 1997. In 2012, GlaxoSmithKline paid a $3 billion fine for promoting the unapproved use of Dosier in weight loss and sexual dysfunction.

Other names for this medication:
Bupropion, Amfebutamone, Aplenzin, Buproban, Bupropiona, Buxon, Dosier, Quomem, Wellbutrin, Zyntabac,

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Optical coherence microscopy (OCM) is a low-coherence-based interferometry technology for cellular imaging with both high axial and lateral resolution. Clinical aspects of investigating phyllodes tumors of the breast An analysis of EEG spectral power values and of quantitative clinical scores of depressive conditions has been carried out in dynamics of treatment in 40 patients with endogenous depression with the main goal to study neurophysiologic correlates and to search possible predictors of therapeutic outcome. Bortezomib is a selective and reversible proteasome inhibitor used for the treatment of patients with multiple myeloma (MM).

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The prototypal system also comprises a microcontroller board with a radio communication unit and it is powered by a Li-Ion rechargeable battery. Though the etiology remains unknown, an association with rare retrovirus in some cases has been described. We investigated nasal passage patency after allergen and histamine provocation in patients with allergic rhinitis by acoustic rhinometry. Structure-mutagenicity relationship of kaurenoic acid from Xylopia sericeae (Annonaceae). Considering that RHDVb and genogroup II norovirus similarly interacted with HBGAs, it may be possible that a comparable cell culture system also could work with RHDVb.

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These experiments revealed an internal conversion (IC) process to be on the order of 50-200 fs which is equivalent to the back electron transfer after optical excitation into the intervalence charge transfer band. Detection of antimicrobial peptides related to piscidin 4 in important aquacultured fish. In conclusion, gain-framed messages may evoke greater dwell time than loss-famed messages. After the administration of PSL, laboratory data dramatically decreased. Postdeglutitive residue in vagus nerve paralysis and its association with feeding style.

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The useful typing methods for determining strain relatedness include auxotyping, serotyping, plasmid profile analysis, DNA sequencing of the porB gene and pulsed-field gel electrophoresis. We sought to create a novel delirium prediction system that is specific for abdominal surgery.

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At an average postoperative follow-up of 49 months from the index procedure, patients ultimately had positive outcomes despite advanced degenerative changes on imaging. Additionally, the conserved upregulation of Kv1.3 on phenotypic modulation in several vascular beds makes this channel a good target to control unwanted vascular remodeling. As appropriate instruments are available and relevant surgical experience is accumulating, age should no longer exist as a limiting factor for performing PCNL.

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The precise function of LEAs is still unknown, but substantial evidence indicates their involvement in dessication tolerance as the expression of LEAs confers increased resistance to stress in heterologous yeast system and also significantly improves water deficit tolerance in transgenic plants. A single-item question on sexual bother is strongly predictive of potentially distressing sexual problems in the WSW. Inelastic tunneling spectroscopy for magnetic atoms and the Kondo resonance. Proteases are also implicated in heat shock response, signal peptide processing, cell cycle progression, transcriptional regulation, and signal transduction networks.

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Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis. To understand the typical behaviors of the MSF for various chaotic oscillators is key to predicting the collective dynamics of a network of these oscillators. MRI offers two perfusion methods: the first employing contrast agent (dynamic susceptibility contrast (DSC)-MRI) that provides information on cerebral blood volume (CBV) and cerebral blood flow (CBF), the second by magnetic labeling of blood (arterial spin labeling (ASL)-MRI), providing CBF-images.

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Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease characterized by the presence of a plethora of autoantibodies and immune complex formation. High resolution PCR-SSOP typing methods for HLA-B identification have been established and applied to a Northern Ireland population, using large enough numbers to give dependable allele frequencies.

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Prior research on chronic pain has suggested that social factors may contribute to disability. A weighted average PTE across treatment comparisons was obtained. Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models.

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Intrathecal and epidural administration of non-opioid analgesics in acute and chronic pain treatment. A total of 49 individuals participated in this evaluation, including eight children and nine youth with heart transplants, five siblings, 19 parents, and 13 health care providers.

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PCSK9 and plasma lipids were studied in nephrotic syndrome patients before and after remission of disease, mice with genetic ablation of the podocyte (Podocyte Apoptosis Through Targeted Activation of Caspase-8, Pod-ATTAC mice) and mice treated with nephrotoxic serum (NTS), which triggers immune-mediated podocyte damage. Coupled with this has been the recognition that microRNAs are key mediators of this process within cells. Assessment of Three Risk Adjustment Systems as Predictors of the Consumption of Medicines and Medical Supplies at Polyvalent Hospitalization Units. A brief history, status, and perspective of modified oligonucleotides for chemotherapeutic applications. The present study has confirmed that the combination of in situ MRI and SEC should be well suited to investigate the drug release mechanisms of hydrogel matrix such as PEO/PEG.

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Physiological and functional changes in the stratum corneum restored by oestrogen in an ovariectomized mice model of climacterium. Twenty participants were tested on a number of test and control figures incorporating first-order (luminance-defined) and subjective parallels using the method of adjustment. Dose-specific transcriptional responses in thyroid tissue in mice after (131)I administration. The effect of treatment with interferon-gamma on type II collagen-induced arthritis.

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To determine if c-fos induction was unique to the MC3T3-E1 cell line, effects of IGF-1 and IGF-II (3 ng/ml) were also tested in quiescent, serum-free primary mouse calvarial cells. Improved Survival in Male Melanoma Patients in the Era of Sentinel Node Biopsy. In addition, primary breast cancer tissues from 15 patients were included.

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The mean activation energy for receptor current was 23.1 kcal/mol (96.6 kJ/mol), corresponding to a Q10 value of 3.2. It was revealed that the serotype-4, -12 and -17 GPLs showed strong phagocytosis promotion and marked inhibition of P-L fusion, while serotype-9, -13, -16 and -19 GPLs showed neither promotion of phagocytosis, nor inhibition of P-L fusion in phagocytic cells. Structural basis for the unusual specificity of Escherichia coli aminopeptidase N. ANNOTATIONS: ANTI-VENEREAL MEASURES IN THE SOVIET UNION: Report from the Anglo-Soviet Medical Council.

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A mannose- and glucose-binding lectin bearing considerable sequence similarity to other legume lectins was isolated using a simple procedure, from legumes of the sugar snap Pisum sativum var. Intrinsic and extrinsic NPY nerves in transplanted neuroinsular complexes.

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Surface electromyography analysis of contralateral lower extremity tremor following thalamic hemorrhage. This paper presents a planar waveguide grating sensor integrated with a photodetector (PD) for on-chip optical sensing systems which are suitable for diagnostics in the field and in-situ measurements. The discovery of small non-coding microRNAs has revealed novel mechanisms of post-translational regulation of gene expression, the implications of which are still incompletely understood. Is it possible to limit the duration of the application of amifostine?

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Rule Encoding in Orbitofrontal Cortex and Striatum Guides Selection. To this aim, we developed and combined two mathematical methods that allow us to (i) classify promoters into groups characterized by specific global structural features, and (ii) recover, in full generality, any regular sequence in the different classes of promoters. The in vitro explant culture (IVEC) technique is based on coculture of human gastric explants with H.

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Perioperative AKI is associated with an increased occurrence of CKD and a higher mortality rate after revascularization procedures of the lower extremities. Double chambered right ventricle associated with tricuspid regurgitation--a 54-year-old case Among the 138 cases, 25 had two copies, 84 had one copy, and 29 had null copy of exon 7 of the SMN1 gene.

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This final possibility leads to complex, large-area quantum dot monolayer structures with micrometer spatial resolution that may combine different types of quantum dots. Formation of new stellar populations from gas accreted by massive young star clusters.

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The fact that e-cigarette only users were intermediate in risk status between nonusers and dual users raises the possibility that e-cigarettes are recruiting medium-risk adolescents, who otherwise would be less susceptible to tobacco product use. Together, the data establish Tnip1 as a critical regulator of IL-17 biology and reveal a causal role of keratinocytes in the pathogenesis of psoriasis. Tumor invasiveness and metastasis in cancer progression is manifested by epigenetic abnormality.

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Accumulating lines of inquiry indicate that specific TG isoforms can shuttle into the nucleus when they sense pathologic changes in calcium or oxidative stress, bind to chromatin and thereby transduce these changes into transcriptional repression of genes involved in metabolic or oxidant adaptation. The patient presented with erythematous plaques on the nasal bridge and right thumb. Thus, the aim of this study was to examine whether APD exerted their adverse effects by interfering with the renal antioxidant defense system. Approximately, 77 metabolites have been identified and aliphatic compounds contribute significantly towards the aroma and flavour of this plant.

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Triangulating the results of a variety of data sources and methodologies, and increasing reliance on surveillance of behavioral trends among targeted population groups helped to circumvent numerous methodological problems. She presented evidence of an acute pelvic infection for which an emergency total abdominal hysterectomy with bilateral salpingectomy was performed. The standard Smith-Robinson approach does not allow complete exposure of the C3 body/disk in patients requiring instrumentation of C3 or in patients with a short, thick neck.

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This is the first study to show that EMMPRIN and VEGF may play a role in radiation injuries of the central nervous system after GKS. Virtual medication therapy management: the cornerstone to a pharmacy renaissance.

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Design, synthesis and anti-ulcerogenic effect of some of furo-salicylic acid derivatives on acetic acid-induced ulcerative colitis. We aimed to identify preoperative factors that influence operation time and to determine how operative time affects laparoscopic appendectomy outcomes. Chromatin structure representing a poised transcriptional state (bivalent chromatin), indicated by the occupancy by modified histones associated with both active and repressed transcription, was observed for CYP3A4 and most 3A7 regulatory regions in both postnatal and fetal livers.

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Early work on coral genomics established that corals have a complex innate immune system, and whole-transcriptome gene expression studies have revealed mechanisms by which the coral immune system responds to stress and disease. As the disease progressed, needle electromyography showed diffuse severe denervation changes including thoracic paraspinal muscles. The effect of RA was neither blocked by an RA nuclear receptor antagonist (AGN193109) nor mimicked by a selective RA nuclear-receptor agonist (TTNPB). The aim of our study was to investigate the relationship between metabolic syndrome and Lys656Asn polymorphism in obese patients. The growing body of literature suggests that the dysfunctional autonomic nervous system might play a pivotal role in the pathogenesis of migraine.

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We present a family with four children born to second-cousin parents. Concentrations of disaturated phosphatidylcholine and surfactant proteins were found to be similar at a given stage of pregnancy, with both components showing a similar pattern of increase with progressing pregnancy in fetuses with CDH and in control fetuses. FreeO2 was deemed as an appropriate oxygen administration system by nurses and physicians of a respiratory unit. There was also a significant association between Hb and 25(OH)D levels in infants.

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Multi-level analyses were conducted to test a number of hypothesised relations within the cross-classified hierarchical structure in which teams are nested within QICs and hospitals. There is limited and contradictory information regarding the role of serum ischemia-modified albumin (IMA) in obstructive sleep apnea (OSA). N-(3-dimethylaminopropyl) octadecanamide, the emulsion-like system forms different microstructures. Can Declining Rates of Dementia Be Explained by the Increased and Widespread Use of Psychotropic Medications? Cathepsin L was identified inside the surface of vacuoles in the fresh S.

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With a high specificity, IL-24 gene therapy under the control of ovarian-specific promoter-1 is a novel target for the treatment of ovarian cancer. Use of an over-the-scope clipping device for closure of a jejuno-sigmoid fistula: a case report with long-term follow-up.

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Intrauterine devices are the most used long-acting reversible contraceptive method worldwide. Physiochemical changes in DNA and DNP caused by N-nitroso-N-methylurea The fate of larval chondrocytes during the metamorphosis of the epibranchial in the salamander, Eurycea bislineata. Proceedings of the 13th Scientific Conference on Tobacco smoking in relation to concomitant addictions, November 7-9, 2012, Poznan, Poland.

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Initial experiences with the myocutaneous swing flap-plasty as an expanded possibility for treatment of vulvar cancer Several residues important for dimerization in TREX1 are also conserved in ICP35. Results indicated that individuals with ASD had lower levels of Social Determination and Friendships than individuals with other developmental disabilities.

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Flexible rulers were used to measure the coccygeal branch in five hemipelvises. Early use of novel microdevices for patient monitoring might come in especially handy in new clinical trial designs of emerging therapies. This paper analyses cause-specific mortality in ages 15-30 years in Finland, using longitudinal population register data that covers the period 1970-2004. Phosphocreatine recovery overshoot after high intensity exercise in human skeletal muscle is associated with extensive muscle acidification and a significant decrease in phosphorylation potential.

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The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). Intraoperative Near-Infrared Fluorescence Imaging using indocyanine green in colorectal carcinomatosis surgery: Proof of concept. They were mediated by an opiate receptor of the mu type since they were obtained with the mu-preferring enkephalin analogues FK 33-824 and DAGO, but neither with the delta nor the kappa analogues such as DPLPE or U-50,488. 2 scores, 2) measured tumor size on axial T2 -weighted-MRI, and 3) assessed for extraprostatic extension (EPE).

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The current findings suggest that disorganized memory structure may be one process that impedes access to, and modification of, trauma-related cognitive schema. Comparison of Gd-DTPA and Gd-BOPTA for studying renal perfusion and filtration. The Protein Data Bank (PDB) is an archive of experimentally determined three-dimensional structures of proteins, nucleic acids, and other biological macromolecules with a 25 year history of service to a global community.

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A patient with a clinical and angiographic diagnosis of nonocclusive mesenteric ischemia had phenoxybenzamine directly infused into the superior mesenteric artery to counteract the existing splanchnic vasoconstriction. A retrospective medical record review was conducted for patients aged 18 years and under who received adjustable suture strabismus surgery using short tag sliding noose with pull-string technique. Morphological and functional changes of stallion spermatozoa after cryopreservation during breeding and non-breeding season. keftab dosage index Training Family Medicine Clerkship Students in Screening, Brief Intervention, and Referral to Treatment for Substance Use Disorders: A CERA Study.

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The quest for liver progenitor cells: a practical point of view. The psychiatric ratings, using the In-Patient Multi-dimensional Psychiatric Scale, of (1) a group of over 200 psychiatrists from the British Isles, (2) third year psychology students, (3) trainee sister tutors, (4) general practitioners attending a postgraduate course in psychiatry, pyrantel vs mebendazole and (5) a group of new registrars at the Maudsley Hospital, were compared. Measuring CD4 T-cell counts at low cost is relevant in dealing with the human immunodeficiency virus (HIV) epidemic throughout the developing world. We examined responsiveness of the TIMP-3 gene to OSM in articular chondrocytes and studied the regulatory and signaling mechanisms of this response.

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The results obtained indicate that the NR1, NR2A and NR2B subunits of NMDA receptor may participate in the glutamatergic neurotransmission from photoreceptors to second order retinal neurons, as well as from bipolar cells to third order retinal neurons. Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation. Posterior, lateral, or anterolateral minimally invasive approaches to the hip should take into account the point of exit of the SGN and the area of distribution of its branches. Procedural pain and anxiety were evaluated in children and adolescents (8-16 years) who were admitted to the emergency department of a paediatric hospital allopurinol alcohol liver detox between February-September 2010. The site of the graft harvest is the lateral mucosal lining of the tongue.

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Increasing evidence suggests that thoughtful lipid management what is the banana flavoured medicine called gabapentin for coronary prevention should include a more complete assessment of lipoproteins with an emphasis on apolipoproteins, triglycerides, and very low-density (VLDL) remnant particles, LDL particle size, and lipoprotein(a). Two-photon intravital imaging of lungs during anthrax infection reveals long-lasting macrophage-dendritic cell contacts.