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Fulvicin (Griseofulvin)

Fulvicin, an antifungal drug, has recently been shown to inhibit proliferation of various types of cancer cells and to inhibit tumor growth in athymic mice. Due to its low toxicity, Fulvicin has drawn considerable attention for its potential use in cancer chemotherapy. This work aims to understand how Fulvicin suppresses microtubule dynamics in living cells and sought to elucidate the antimitotic and antiproliferative action of the drug.

Other names for this medication:
Griseofulvin, Grifulvin, Fulcin, Fulvicin, Fulviderm, Fungistop, Grifulin, Grisetin, Griseofulvina,

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Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo. Half of the patients hospitalized in intensive care units have a central venous catheter (CVC) inserted. A limit-of-detection of 100 nM was demonstrated for Rhodamine 6G, and 10 microM for fluorescein. MiR-23 in the embryonic heart is required to restrict endocardial cushion formation by inhibiting Has2 expression and extracellular hyaluronic acid production. Colchicine prevents tumor necrosis factor-induced toxicity in vivo.

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Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers offer renoprotection to a small extent beyond that attributable to blood pressure lowering. To explore the relationship between gamma-synuclein gene expression and CpG island demethylation in colorectal cancer(CRC), and the relationship between the demethylation and clinicopathological factors of CRC.

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To calculate capillary forces, first the gap between the two surfaces is described by a height distribution function. MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics.

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The high-risk groups identified in this study require increased clinical surveillance. We discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with overlooked advantages that this type of agents might have in clinical trials.

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