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Eligible studies were identified from electronic databases (Medline, Embase Cochrane) and cross-reference search. Rhabdomyosarcoma presenting with destructive large lesion of the face. Linear Raman spectroscopy offers a wealth of chemical and molecular information. The activity of phenylalanine hydroxylase in the liver without the cofactor 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropterin is similar in cases of classical PKU (14 cases), mild hyperphenylalaninemias (2 cases), heterozygotes (1 case) and normal controls (18 cases).

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