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Orfarin (Warfarin)

Orfarin is an anticoagulant medication that is highly effective at preventing clotting disorders but which has a narrow therapeutic window. If Orfarin is under effective patients are at risk of stroke, if it is over effective patients are at risk of bleeding complications. Physicians routinely and regularly measure a blood test (called the "INR") that determines the effectiveness of Orfarin and have a range of test values (the "therapeutic range") in which they try to keep the patient. By convention Orfarin is taken at dinnertime, however this is the same time of day that highly variable consumption of dietary vitamin K occurs (found largely in green leafy vegetables) and vitamin K alters the effectiveness of Orfarin. Given vitamin K has a very short half-life (i.e. it is only active for a short period of time after it is ingested) it may make more sense to take Orfarin in the morning (when very little vitamin K is ingested) to produce a more consistent drug effect. The purpose of this study is to determine whether switching current Orfarin users from evening to morning dosing decreases time spent outside the therapeutic INR range.

Other names for this medication:
Warfarin, Coumadin, Aldocumar, Circuvit, Coumadine, Hemeran, Jantoven, Kovar, Marevan, Marivarin, Martefarin, Orfarin, Panwarfin, Simarc, Warafin, Warfarina, Warfarine, Warfin, Warin, Warlin,

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Severe pre-eclampsia affects maternal health with long-term consequences. No specific inhibitors of repair are known, and care must be taken when interpreting results to be sure that observed effects of inhibitors unambiguously relate to repair.

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Studies examining the presence of negative symptoms in ultra-high risk (UHR) populations have shown some limitations, notably failing to control depression. The proposed treatment strategy could be applied elsewhere in Russia and in other settings where TB control is jeopardized by AUDs. communis, namely giant fennel, has extensively been used in traditional medicine for a wide range of ailments.

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Our data strongly suggest that epigenetic regulation may underlie conserved germ-cell-specific expression, and such a mechanism may play an important role in human fertility.-Zhang, C., Xue, P., Gao, L., Chen, X., Lin, K., Yang, X., Dai, Y., Xu, E. For this purpose, 39 hybrid combinations were evaluated under low- and high-nitrogen and -phosphorus availability. The roles of vascular endothelial growth factor in bone repair and regeneration. In addition, the ability of the T cell to secrete interleukin-2 (a cytokine necessary for the recruitment of other T cells) declines with age. In order to study the problem how the olfactory neural system processes the odorant molecular information for constructing the olfactory image of each object, we present a dynamic model of the olfactory bulb constructed on the basis of well-established experimental and theoretical results.

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Dimercaptosuccinic acid scan or ultrasound in screening for vesicoureteral reflux among children with urinary tract infections. To determine whether there is an optimal time period to perform intracytoplasmic sperm injection (ICSI)/embryo transfer cycle after hysteroscopic resection of an incomplete uterine septum. MCC is a heteromeric mitochondrial enzyme composed of biotin-containing alpha subunits and smaller beta subunits. Finally we recognize that by working in partnership with like-minded advocacy organizations, the IUHPE could put its significant knowledge and experience to work in leading action to transform health care systems to make a major contribution to the improvement of public health.

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This review discusses the recent advances in breath analysis for the diagnosis of bacterial and fungal lower respiratory tract infections. Adhesion of composite restorative materials to dentin is not affected by the location of the margins. Genomic annotation, secondary protein structure prediction, and comparative genomic analyses of TCSTS genes reviewed here provide insights into our understanding of signal networks in these important phytopathogenic bacteria. Comparative analysis of genetic structure of two groups of Red Polish cattle, which reproduce in Poland and Ukraine, was made. Combined Pharmacological and Genetic Manipulations Unlock Unprecedented Temporal Elasticity and Reveal Phase-Specific Modulation of the Molecular Circadian Clock of the Mouse Suprachiasmatic Nucleus.

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In 11 Tibetan individuals out of 30, YAP element is present and the PCR product is 455bp. Localisation of mycobacterial DNA and mRNA in human tuberculous granulomas.

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Medication Safety Systems and the Important Role of Pharmacists. A CT scan with angiography showed a small high-density area in the jejunal lumen, suggesting extravasation of the contrast media.

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334 randomly selected health workers involved in the PMTCT programme completed self-administered questionnaires. Overall 36 patients with diffuse fatty liver who had undertaken the computed tomography (CT) scan, MRI and proton MR spectroscopy (1H MRS) were analyzed. Neutrophil CD64 serves as a sensitive and reliable biomarker for the diagnosis of bacterial infection in hematological disorders.

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MicroRNAs (miRNAs) have been shown to be critical mediators of many cellular and developmental processes and have been implicated in different human diseases. These results suggest that increased miR-138 is associated with better memory and increased APT1 gene transcription occurs with aging. Nurse managers at all levels have a stake in the well-being and job satisfaction of clerical workers in patient care areas. An ELISA was successfully established and penicillin reactive IgG response in children was heterogeneous.

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Hydrogen-bond dynamics are expressed in terms of hydrogen-bond population autocorrelation functions and are found to be nonexponential. From Mar 2011 to Aug 2011, 4,833 female workers in the manufacturing, finance, and service fields at 16 workplaces in Yeungnam province participated in this study, conducted in combination with a worksite-based health checkup initiated by the National Health Insurance Service (NHIS). FLI-06 also inhibits export out of the trans-Golgi network (TGN), suggesting that similar mechanisms might orchestrate cargo selection and concentration at the ER and TGN. For selected grade 2 and grade 3 AC, early percutaneous cholecystostomy (PC) followed by delayed cholecystectomy is recommended.

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Training must include details of various regulations and guidelines, proper handling and care for animals, proper pre-procedural and post-procedural care of animals, aseptic surgical methods and procedures, proper use of anaesthetics, analgesics and tranquilisers, methods whereby deficiencies in animal care and treatment are reported, and a search for alternatives to the use of animals. Towards a truly integrative biology through the functional genomics of yeast. As a result, audiologists are likely to see an increased demand for service by older clients whose communication difficulty is caused by a combination of hearing loss and cognitive impairment. Herein, we report the effects of pH and protein concentration on the oligomerization of Nterm-Lsr2.

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As a result, restraint and lack of communication form serious barriers for both patient and provider in their interaction. In approximately half of the patients for whom percutaneous radiofrequency ablation of HCC is requested, the procedure is not feasible, mainly due to inconspicuous tumors, at planning sonography. We found that the pVHL (residues 157-171) is necessary and sufficient for binding to elongin C in vitro and is frequently mutated in families with VHL disease. Chronic peritoneal dialysis in South Asia - challenges and future.

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Our results suggest that Ni(II)-induced changes in cytokine secretion by monocytes are diverse and may be influenced by Nrf2 but are not likely influenced by changes in whole-cell Trx1 levels. The epithelium lining the cysts were positive for CK8, CK14, CK18, CK19, and negative for SMA, S-100, and p63 immunohistochemically. Flexible, scalable, and efficient targeted resequencing on a benchtop sequencer for variant detection in clinical practice. Amino acid periodicities and their structural implications for the evolutionarily conservative central domain of some silkmoth chorion proteins. Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography.

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Embryos with relatively high monooxygenase activities also displayed a high incidence of embryonic abnormalities when cocultured with AAF. Comparative Evaluation between Sulfasalazine Alone and in Combination with Herbal Medicine on DSS-Induced Ulcerative Colitis Mice. Treatment of UTI led to spontaneous healing of the lesions in short period thus avoiding the need of oral corticosteroids.

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Unexposed His-allele carriers reported a mean of 3.6 AUD criteria, but adversity-exposed His-allele carriers endorsed approximately the same number (6.3) as those without the protective allele (6.3 and 7.0 for adversity-exposed and -unexposed groups, respectively). IL-13R alpha 2, EphA2, and Fra-1 are attractive therapeutic targets representing molecular denominators of high-grade astrocytomas. This compound produced robust antiallodynic activity in rodent models of postoperative pain and neuropathic pain without traditional cannabinergic side effects. As a comparative study, 10 microg of linoleic acid (LA) dissolved in 5 microl of SBB was injected in the same way. Temperature and pH had a strong influence on the production of the two bacteriocins which was stimulated by slow growth rates.

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We therefore recommend careful monitoring of patients with BD in terms of muscle strength. Eleven of the 22 survivors were contacted, and 10 completed the survey. Lack of initiation activity of 4-oxo-2-hexenal, a peroxidation product generated from omega-3 polyunsaturated fatty acids, in an in vivo five-week liver assay. The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. Mobile meniscoids, particularly fibrous ones, can get wedged between articular surfaces due to a sudden, rush movement (entrapment theory) or can be caught between the edge of an articular surface and the articular capsule attachment (extrapment theory).

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Afterwards, they conducted a pointing task from multiple body orientations to infer the underlying reference frames. The results were as follows: (1) When blood pressure was increased, the left ventricle became hypertrophic, alpha-MHC gene expression was reduced and beta-MHC gene expression was increased in 2K1C renal hypertensive rats. The autosomal recessive form of the disorder appears to be controlled by a set of genes coding for soluble cofactors essential for oxidase expression. Borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while (18)F-fluorodeoxyglucose ((18)F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. These findings indicate that active hepatitis and extensive fibrosis are responsible for the development of multicentric HCCs.

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Males and Females Pace Differently in High School Cross-Country Races. For many inhibitor classes, no detailed crystallographic data are available. We encourage additional research in this area, particularly in the context of HIV-1 infection. Furthermore, the wettability on the inner surface was measured using a liquid within the same CNT. The development of new technologies is affording a better understanding of how diet influences gut microbiota composition and activity and how this may, in turn, influence depressive illness.

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Night-time driving difficulties are a common concern of older drivers and those with eye disease. Nuclear entry and nucleolar localization of the Newcastle disease virus (NDV) matrix protein occur early in infection and do not require other NDV proteins. Musicians and non-musicians similarly perceived the parchment-skin illusion.

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These results support a middle-ground position in which disgust words concerning socio-moral violations are not entirely a metaphor for anger, but bear some relationship to other representations of disgust. HOPS is a newly discovered protein isolated during liver regeneration, implicated in cell proliferation. CGG repeat interruptions in the FMR1 gene in patients with infantile autism.

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anguillarum significantly affected all parameters measured, to a different extent and at different times p.i. Coronary artery-bronchial artery fistulas: report of two Dutch cases with a review of the literature. The thereby generated radicals are usually utilized in aqueous systems for the degeneration of organic pollutants.

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The effect of retinol deficiency on the metabolism of all-trans-retinyl acetate in rat testes. A new technic of intraoperative radiotherapy: the Lyon intraoperative device Implications of our analysis for resolving current issues and prompting new research are discussed.

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Our operative times were decreased with this technique, and our outcomes were similar to other laparoscopic Whipple series. Influence of starvation on the activities and localization of cathepsin D and other lysosomal enzymes in hearts of rabbits and mice. Serological survey for brucellosis in sheep and goats in Guyana. Oxaliplatin and related chemotherapeutic drugs cause painful chronic peripheral neuropathies in cancer patients. The results from the present study suggest that the lower immunoreactivities of TH in locus coeruleus and inferior colliculus contribute, at least in part, to the noradrenergic deficits in GEPRs, and repeated seizure experiences further intensified these noradrenergic deficits, which may be related to the altered seizure expression by repetitive audiogenic seizure in GEPRs.

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This activity paralleled the extent of chlorine substitution and was further enhanced in the dihaloacetonitrile series when bromine was substituted for chlorine. Palliative care for those who need it should be an integral part of National Health Service (NHS) practice in all settings in the UK. The study included patients diagnosed with RA (ACR 1987), AS (modified New York criteria), JCA (European 1977 criteria), and osteoarthritis (OA) (ACR 1990 criteria) with unilateral or bilateral THR. Other investigators have reported ventricular subendocardial hemorrhage, increased elastic and fibrous tissue in the left ventricle endocardium, and opacification of the mitral valve leaflets.

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These results provide an improved understanding of the effects of electrode placement, geometry, and polarity on the outcome of ECS and can facilitate the rational implantation and programming of ECS systems. An MRI revealed a complete occlusion of the right M1 segment with an area of restricted diffusion in the right basal ganglia representing only a small area of acute infarction. The aim of this study was to determine the immediate and long-term (12-18 months) histologic and clinical effects of atrophic acne scars after CO2 laser resurfacing in order to provide physician guidelines for postoperative clinical assessment for retreatment.

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Here, we show that for extra electrons confined in a single ferromagnetic-metal MnAs nanoparticle embedded in a GaAs semiconductor matrix, the spin-relaxation time can reach 10 micros at 2 K, which is seven orders of magnitude longer than those of conventional metallic thin film or bulk systems, and the longest value ever reported for metallic nanoparticles. Abuse by adults has been reported as a potent predictor of borderline personality disorder (BPD).

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These results suggested that deletion of both subunits affected the PSII activity, thereby destabilized PSII, leading to a decrease in the PSII content in vivo. With reference to its founder Karl Jaspers, the phenomenological method is presented as the decisive instrument for the assessment of experience. On a variety of fronts, chronic bacterial infection is being found to be significantly associated with the development of atherosclerosis and the clinical complications of unstable angina, myocardial infarction, and stroke.

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All injured adult patients who were admitted to a participating hospital through the ED during consecutive three-month periods from June through November 1989. Enhancing communication in dental clinics with linguistically different patients. An international consortium of clinicians, scientists, and affected families was formed.

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After a normal development in the first year of life, neurological regression occurred since the beginning of the second year. Hygienic quality of traditional processing and stability of tomato (Lycopersicon esculentum) puree in Togo. The displaced mandibular third molar is a rare but potentially serious complication of extraction. Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin T assay. The main purpose of this review is the analysis of the expression patterns of AP-1 transcription factors in order to gain insight into the histophysiology of lymphoid tissues and the pathology of lymphoid malignancies.

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The LE outcomes of patients treated prior to initiation of the SLYM were compared with those of patients after SLYM implementation. We developed a surgical filter suction system that we call the VY suction tube.

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Ribonucleic acid was extracted from the diaphragm of control, emphysematous, emphysematous and sham operated and LVRS hamsters and subjected to reverse transcriptase polymerase chain reaction. In this paper I argue that such a lock-in might have been avoided if an experimental approach to governance had been adopted. This study examined the N2 and P3 NoGo effects elicited by five sets of auditory stimuli varying in perceptual similarity. Estrogen administration attenuated glomerular injury in male Imai rats, and the aggravating effect of ovariectomy in female rats is found.

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A Stroke Unit like the Scandinavian model may be beneficial in preventing delirium. Body mass index and periodontal infection in a sample of non-smoking older individuals.

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We consider the highest priorities for a future monitoring program to be: (1) establish whether edge effects are occurring at well sites, along roads and along the planned pipeline route and determine the significance and extent of these effects and (2) assess the impact of increased human access to the area on game and other exploited species. Spatial-time cluster analysis of distribution of schistosomiasis in Jiangling County

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The evolution of resistance mutations in blood and semen were frequently discordant, although over time similar patterns were seen. Pooled shRNA Screening in Mammalian Cells as a Functional Genomic Discovery Platform. Relation of time since last birth and parity to survival of young women with breast cancer.

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The feasibility of using indirect stereo-lithography (SL) to produce scaffolds from calcium phosphate cement materials for bone tissue engineering has been investigated. This HAI was caused by poor practice in the preparation of medications for nebulization and intravenous infusion, hygiene practices, and a lack of awareness among staff about infection control. Diuretic efficiency of furosemide during continuous administration versus bolus injection in healthy volunteers. This is, to our knowledge, the first reported case of a patient with gastric mucosal cancer who presented with a conjunctival metastatic deposit and who subsequently received curative surgical treatment for both conditions.

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An attempt was made to develop a new method of microsurgery of the larynx. We describe a new case with lethal outcome and we discuss the radiographic and pathologic findings. This study was set up to investigate the association between potential predisposing factors, including new therapies recommended in CF, and the occurrence of AC or ABPA in children with CF. Patients who had revision because of femoral component loosening had worse outcomes than those who had revision because of femoral neck fracture or femoral head collapse or osteonecrosis. Such compact and demonstrative amino acid sequence comparisons can make easy the identification of differences at clarithromycin 500 mg film-coated tablets at best the DNA level if not seen in amino acid sequences (e.g.

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Dominant disease sites were soft tissues in 7 patients, visceral in 12 patients, and bone in thuoc alfuzosin hydrochloride er 4 patients. Detection of Mycobacterium tuberculosis complex by nested polymerase chain reaction in pulmonary and extrapulmonary specimens. All components of NEC model are necessary for increased NOX activity.

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We present a case of a 23 year old female with enterobiasis of appendix presented with clinical features of acute appendicitis. The influence of the addition of salts to the subphase and of varying the lipid pharex clarithromycin price philippines composition was analyzed. Chloroprocaine-bupivacaine sequence for obstetric extradural analgesia. Short-term exercise-based cardiac rehabilitation induced changes in cardiorespiratory, mechanical and neuromuscular responses to progressive exercise testing The reasons for this are unclear and have sometimes been attributed to socio-economic differences.

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Principles christopher sergel to kill a mockingbird reviews on garcinia of diagnosis and treatment of hormonally active tumors of the digestive tract Eventually, the inhibition of AKT led to insulin resistance in PFOS-treated cells. Deviation from normal weight results from an imbalance between caloric consumption and energy expenditure.

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More broadly, a paradigm shift among researchers and funders alike is aristogyl f syrup for snow needed to galvanize the commitment and resources necessary for conducting collaborative clinical trials with this highly vulnerable population. Pretransplant donor antigen and cyclophosphamide in the evaluation of the clonal deletion theory in the hamster to Lewis rat cardiac xenograft model. The anterior side of the anastomosis was augmented by using pulmonary autograft patch and this patch was extended to the inferior surface of the archus aorta. If the damaged lesions are successfully repaired, the cells will survive.

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Multiplex MALDI-TOF MS detection of mitochondrial variants in Brazilian patients with hereditary optic neuropathy. This study aims to examine the prevalence and bacteriological findings of different types of intrauterine fluid collection in women presenting with postmenopausal bleeding and the risk factors for predicting positive microbiological culture, mixed growth, and anaerobic growth. Cytotoxicity was screened by brine shrimp lethality bioassay using vincristine sulfate (VS) as positive control. However, when cells were preincubated in the presence of DEX for 15 h and then challenged with IL 1beta or IL 1beta and DEX, there was a left-shift in the IL 1,B dose-response curve, suggesting an increased sensitivity of the cells to respond to seroxat cr 12.5 mg uses IL 1 and produce IL 6.

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Presence and severity of PTSD were determined in the children and their parents through a validated diagnostic questionnaire 7 to 12 months after child injury. However, the direct transmission of an image through an optical fibre is difficult because spatial information is scrambled upon propagation. The revised classification of renal cell carcinoma was a significant predictor of cause specific survival for the cohort of patients described in this report. CASE REPORT Temporomandibular Joint Arthroplasty soltrim trimetoprima y sulfametoxazol suspension With Human Amniotic Membrane: A Case Report.

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In this paper it is demonstrated that amoxycillin disposition kinetics in rats is clearly nonlinear, and that this may be due mainly to its elimination mechanisms. Conversely, under pathological condition, this pathway relayed aberrant cerebellar activity to the basal ganglia to cause dystonia. Intraspecific variation in M1 enamel development in modern humans: implications for human evolution. The proposed methods allow the PWER and FWER to be controlled in various MAMS designs, potentially increasing the uptake of the MAMS design in practice. Movement of the spermatozoon into the oocyte and chromatin remodeling for the formation of pronucleus seem to occur independently and are possibly directed lordin 40 mg by different mechanisms.

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Matrix-free application of Hamiltonian operators in Coifman oxybutynin price uk used blackberry wavelet bases. Baseline neurocognitive testing has been recommended to provide more accurate representation of the preconcussion cognitive status of individual athletes. Since one or more var genes encoding the CSA ligand have been identified, it is likely that peptides will be obtained quickly and used either for direct inhibition of cytoadherence on CSA or for development of an anti-sequestration vaccine. four probe resistivity measurements with and without applied magnetic field in the temperature range of 2-380 K, show the effect of secondary grain growth on the magnetoresistance (MR) behavior of LPMO manganites. Construction of new primer sets for corresponding to genetic evolution of human adenoviruses in major capsid genes through frequent recombination.