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In this study we demonstrate the usefulness of plant pollen tube based assay for screening small chemical compound libraries for new biologically active compounds. Active state estimation for nonlinear systems: a neural approximation approach. Implantation meets intervention: retrograde wiring for coronary vein angioplasty during CRT implantation.

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Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. Addition of targeted therapy in second-line treatment is beneficial when compared with chemotherapy alone. Homeostatic role of Toll-like receptor 4 in the endothelium and heart. A cerebellar role in emotional and affective processing and on personality characteristics has been suggested. Exosomes are 30-100 nm membrane vesicles of endocytic origin, mediating diverse biological functions including tumor cell invasion, cell-cell communication and antigen presentation through transfer of proteins, mRNAs and microRNAs.

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Gender differences in the association between stop-signal reaction times, body mass indices and/or spontaneous food intake in pre-school children: an early model of compromised inhibitory control and obesity. marcescens in glucose-rich medium strongly stimulated biofilm formation, which contrasts with previous studies showing that biofilm formation is inhibited by glucose in Escherichia coli and other enteric bacteria. The fully ripened fruit of Katsura-uri Japanese pickling melon ( Cucumis melo var.

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The seasonal dynamics of neutral genetic diversity and the insecticide resistance mechanisms of insect pests at the farm scale are still poorly documented. Detection efficiency and minimum detectable activities for selected radionuclides and several measurement configurations are presented. Streptococcus dysgalactiae cellulitis and toxic shock like syndrome in a Brown Swiss cow.

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The focus of this paper is to address the issue of how incident intensity affects LSCI results. Since the implementation of those measures in 2013, physics experiments with accelerated radioactive isotopes of Rb, Sr, K, and Mg have been performed. These EVs are first described in gastrointestinal stromal tumor cells in the present study. This study examined the peer dynamics linking early adolescent problem behavior, school marginalization, and low academic performance to multiple indices of late adolescent violence (arrests, parent report, and youth report) in an ethnically diverse sample of 998 males and females.

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Normative modeling provides a natural framework to study disorders at the individual participant level without dichotomizing the cohort. Low activity of antithrombin III leads to high content of fibrinmonomeasured complexes in combination with reduction of the thrombocytes quantity and to hypercoagulation. An unusual type of mixed totally anomalous pulmonary venous drainage in an 11-year-old boy was diagnosed on angiography. Different polymers decompose in different ways and fire retardants act to inhibit the decomposition or flaming combustion processes. Meta-analyses for joint injury of the lower limb, knee, and ankle were performed using a random effects model.

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The dominant population was alternate and in some order: running Ciliata, Epistylis and Opercularia, Rotifers, then Aeolosomatidae. Model results suggest that elevated venous pressure and altered flow can trigger inflammatory cascades in the vein wall and venous valves which can cause progressive valvular incompetence and eventual valvular destruction, and which are also important in the skin changes associated with venous disease.

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Effect of interchanging two composite resin system with a dentine adhesive. The strain grading process necessarily introduces misfit dislocations into a heterostructure, and these defects introduce lateral strain inhomogeneities, mosaic tilt, and threading dislocations. Contrary to previous reports, we did not find any significant accelerating effect of hypertension, cardiovascular disease and diabetes on ANM. Traditionally, repair of complex arch and descending aortic disease has required a two-stage surgical approach.

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Primary malignant adrenal masses with venous thrombosis have a poor prognostic outcome. The birefringence patterns were then examined and the impact resistances determined: these were then compared with those of control groups, tested simultaneously.

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Using stratified and multistage probability sample data, five components of metabolic syndrome were adopted to identify health inequalities. CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE.

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In a previous meta-analysis, antegrade intramedullary pinning was shown to produce better hand function outcomes than percutaneous transverse pinning or miniplate fixation for treatment of fifth metacarpal neck fractures. Here we use single femtosecond pulses shaped into high-angle Bessel beams at microjoule energy, allowing for the creation of very high 100:1 aspect ratio voids in sapphire crystal, which is one of the hardest materials, twice as dense as glass. Although pediatric heart transplant recipients experience significant symptomatic improvement, they remain at-risk for impaired psychosocial QOL, similar to children with residual or palliated heart disease. Using custom-made chips or next-generation sequencing to uncover the effects of rare variants on the disease can be very expensive in current technology.

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We have investigated the potential role of Igf2 expression during liver carcinogenesis. Our study showed that the post-mortem processes were associated with apoptosis in skin cells.

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It also seems consistent with the hypothesis that environmental factors interfering with this pathway can play a role in the pathogenesis of TDS. Runt-related Transcription Factor 1 (RUNX1T1) Suppresses Colorectal Cancer Cells Through Regulation of Cell Proliferation and Chemotherapeutic Drug Resistance. Telemedicine: application of telepathology-remote microscopy for intraoperative diagnoses on frozen sections.

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The combination of docetaxel with molecularly targeted therapies may offer the potential to increase the efficacy and decrease the toxicity of cytotoxic chemotherapy for prostate cancer. Since its discovery some 25 years ago, much has been learned about HIV type 1 and the molecular details of its replication cycle. Viral genome sequences can also inform on likely phenotypes including drug susceptibility or neutralization serotypes. The CONUT score was an independent predictor of OS and RFS before treatment and was superior to PLR, NLR, and GPS in terms of predictive ability for prognosis in patients with resectable thoracic ESCC.

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Economic evaluation is important to critically evaluate clinical interventions and ensure that we are implementing the most cost-effective management protocols. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway. Clinical Utility of the Envelope Task in Mild Cognitive Impairment and Dementia.

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These model organisms all allow loss-of-function mutants to be generated easily on a genome-wide scale: yeasts have a haploid stage in their reproductive cycles and the latter two organisms have short generation times, allowing mutations to be systematically bred to homozygosity. Despite her large posterior circulation aneurysm in the setting of AIDS with extensive coccidioidomycosis meningitis, the lesion was clipped successfully. Pharmacological correction of disorders of the prostacyclin- thromboxane balance in ischemic heart disease: problems and prospects We present a novel probabilistic framework to learn across several subjects a mapping from brain anatomical connectivity to functional connectivity, i.e.

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These findings imply that some serpins are part of a quality control system that monitors the export and possibly import routes of eukaryotic cells. Critically ill children have high prevalence of vitamin D deficiency. Lipofuscin-like fluorophores can result from reactions between oxidized ascorbic acid and glutamine.

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PT-FLASH is more prone to misregistration of the respiratory cycle or the ECG by the external monitoring device used for acquisition. Our studies reveal a mechanistically unique heterosynaptic PP1 gate that is constitutively driven by background DA to influence LTP induction. The seismicity data indicate that alteration in ocean lithosphere may reach far deeper than previously thought, with important implications towards seafloor deformation and fluid circulation.

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A Rigid Nested Metal-Organic Framework Featuring a Thermoresponsive Gating Effect Dominated by Counterions. To improve the time/temperature stability of the PCM, novel operation modes of the device should be identified. Temporal lobe epilepsy of right-sided versus left-sided origin may also be a risk factor for sexual dysfunction. Statistically significant predictive factors for PSA bounce were age, V100, V150, V200, iPSAmax and median time to PSA nadir.

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Among all VEGF-A exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angio-genic VEGF-xxx to anti-angiogenic VEGF-xxxb. Citizen security observatories: tools for decision making and governability In addition, the intracranial cavity volume (ICV) was measured manually. This study sought to assess motor inhibitory control and aspects of cognitive flexibility in a sample of individuals with PSP. Vascular lesions produced as a consequence of surgical spinal treatment are rare, but serious.

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The possibility that certain psychologic factors lead to hypertension has been considered by many investigators over the past 60 years, but prospective studies with suitable methods to evaluate this hypothesis were not available for analysis until the 1990s. TDL still remains a problematic entity clinically, radiologically, and sometimes even pathologically. rivulata resembles the paradigm of southern genetic richness and northern purity of European biota. Clinical analysis of 111 patients with non-invasive fungal rhino-sinusitis

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The cDNAs inserted into the anoikis-resistant NIH3T3 clones were amplified using retroviral specific primers. Consequently, this leads to a lower quantum efficiency of high rate of direct I-----QA reaction is normally due to the specificity of the primary quinone species and its binding site in the reaction centre protein which provide optimum steric and chemical conditions for an effective interaction between I and QA. Elderly patients with GERD usually present with atypical manifestations, and they tend to develop more severe disease.

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The objectives of this study are to describe racial/ethnic differences and clinical/treatment correlates of worry about recurrence and examine modifiable factors in the health care experience to reduce worry among breast cancer survivors, partners, and pairs. We aimed to estimate the prevalence of nasal carriage and to explore demographic differences between S.

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Size-Dependent Electrophoretic Deposition of Catalytic Gold Nanoparticles. Of the 132 patients included 93 were reevaluated 6 months after transurethral prostate resection. They used multiple logistic regression to examine the association between chewing tobacco use and root-surface caries. It can be assumed that the EMEA will shortly follow the FDA, so that the validation of instrument software systems will become the rule and create new responsibilities for operators and inspectors.

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We conducted a prospective cohort study on a convenience sample of ED health care workers, including nurses, physicians, and technicians. nov., isolated from a seawater sample reports the presence of pathogenic genes similar to Vibrio genus. A prospective, randomized, controlled crossover study was performed in which 32 patients were randomized into two groups.

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A subset of patients consented to correlative studies including tumor tissue for human papillomavirus (HPV) detection and expression of DNA repair genes that may be predictive of response or resistance to oxaliplatin or pemetrexed. Body-on-a-chip systems replicate the size relationships of organs, blood distribution and blood flow, in accordance with human physiology.

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Organized programs for vaccine delivery can lead to substantial improvements in vaccination rates for the elderly. The applicability of nanoscale mid-infrared (mid-IR) spectroscopy for the study of the micro- and nanostructure of pharmaceutical drug-polymer systems was explored. Human monocyte-derived macrophages were treated with recombinant IFN-gamma or conditioned medium from activated peripheral blood mononuclear cells for 3 days. We report a case of metabolic syndrome in a 63-year-old obese man with atherosclerosis and low-grade RAS that was an important sign of cardiovascular risk.

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A first step in IL-2 signaling is the activation of several protein tyrosine kinases that phosphorylate a large array of intracellular substrates including the receptor complex. We present a 45-year-old female patient who developed diaphragmatic rupture and secondary hernia following a diaphragmatic resection for a diaphragmatic abnormality with spontaneous pneumothorax performed by endoscopic stapling in video-assisted thoracoscopic surgery (VATS). Based on clinical trial results, the oral anti-coagulants rivaroxaban, apixaban, and dabigatran etexilate have been approved in many countries for the prevention of VTE in patients after elective hip or knee replacement surgery. The unique disability-focused data from a genetic subsample of the 1999 National Long Term Care Survey linked with Medicare service use files. Solutions include better education of the medical community, which remains surprisingly ignorant about these disease processes and therapeutic advantages of exercise and sleep repletion.

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Availability, accessibility and promotion of smokeless tobacco in a low-income area of Mumbai. These plates offer the possibility, in the next future, to replace the conventional screen-film systems. Osmium-zinc iodide reactivity in human blood and bone marrow cells. It was hypothesized that the accelerated executions, as compared to the normal executions, would have a different effect on L5/S1 resultant moment, body posture, and other kinematic variables. The results of the present study are the first to demonstrate that MSI2 is a valuable marker of advanced, serous ovarian cancer and that MSI2 plays an important role in paclitaxel resistance.

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The purpose of this study was to assess the mechanical performance of biocomposite knotless lateral row anchors based on both anchor design and the direction of pull. 5 patients have an anterior laxity and only 2 an anterior instability. The purpose of the present study was to investigate if suboptimal health also predicts non-permanent employment. Relationship marketing of health care plans: retaining corporate customers in a competitive environment.

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Spatiotemporal in situ hybridization in zebrafish embryos established for the first time that fadd is expressed during eye development. Using self-reported data, clinical examinations and analysis of non-fasting blood samples, the morbidity in phenotypic and genotypic HH persons was compared with the morbidity in the rest of the population. Evaluating the impact of getting to outcomes-underage drinking on prevention capacity and alcohol merchant attitudes and selling behaviors.

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Demonstration of the low-affinity IgE receptor Fc epsilonRII/CD23 in psoriatic epidermis: inflammatory dendritic epidermal cells (IDEC) but not Langerhans cells are the relevant CD1a-positive cell population. A total of 326 episodes of IE in 303 patients were treated during 1980-2004 in the Turku University Hospital. Univariate, bivariate, and multinomial logistic regression analysis were conducted to identify factors predicting the number of hours worked by IBD patients.

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In 1884/85 the conditions of the foundation of the Pharmaceutical Society were very inconvenient. We discuss issues important in study planning, including quality-of-life definition, priority studies for quality-of-life assessment, eligibility requirements, and design.

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The differences in the polarizabilities of metallic (M) and semiconducting (S) single-walled carbon nanotubes (SWNTs) might give rise to differences in adsorption potentials. H2O2 (250 microm) increased D3 activity with maximal effects around 8 h.