Vigora is used to treat erectile dysfunction and pulmonary arterial hypertension. Originally developed by scientists in the United Kingdom, it was brought onto the market by Pfizer Inc., an American pharmaceutical company. Vigora can help men who cannot achieve or sustain an erection due to erectile dysfunction. It improves the erectile response when a man is already sexually stimulated, but it does not provide sexual stimulation. If there is no sexual stimulation, Vigora will not work. When sexual stimulation occurs, nitric oxide is released by the nervous system in the erectile tissue of the penis. Nitric oxide stimulates an enzyme that produces messenger cyclic guanosine monophosphate (cGMP). cGMP causes the arteries in the penis to dilate, so that the arteries and the erectile tissue fill with blood. An erection results. Vigora prevents cGMP from becoming degraded, so the blood flow and the erection can continue.
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