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Zepatier (Ribavirin)

Zepatier has been an integral component of hepatitis C therapy. The use of Zepatier with interferon or peginterferon for the treatment of hepatitis C is no longer recommended due to the poor efficacy and high rate of adverse effects with this regimen. Currently, still plays a role on a limited basis in combination with some direct-acting antiviral agents and combinations. Dosing of Zepatier is somewhat complicated and includes fixed-dose and weight-based Zepatier, with dosing depending on the genotype and brand of Zepatier used. In addition, Zepatier can cause severe anemia and dose adjustement is required in some patients who develop anemia.

Other names for this medication:
Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, Hepcvir, Incivek, Kipferon, Ledifos, Ledipasvir, Miravirsen, Multiferon, Olysio, Ombitasvir, Paritaprevir, Pegasys, Pegetron, Pegintron, Rebetron, Resof, Setrobuvir, Simeprevir, Sofab, Sofovir, Sovaldi, Sylatron, Technivie, Telaprevir, Veldona, Victrelis, Viroclear, Zepatier,

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Compounds 2 and 4 were revealed to be promising leads, creating a new family of antimalarial agents. beta-Coefficients provided measures of effect and represented the per-unit change in the prevalence of antipsychotic use corresponding to the per-unit change in each independent variable. The repeatability of SDOCT central corneal power measured in vivo was 0.18 Diopters, and the difference observed between the systems averaged 0.1 Diopters between SDOCT and Scheimpflug photography, and 0.6 Diopters between SDOCT and Placido topography.

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Cleavage of different substrates occurred at rates that were determined by their catalytic constants (kcat): the peptidase had the same Michaelis constant (about 30 microM) for all substrates tested. The case of a 54 year old patient suffering from gastrinoma (within a type I multiple endocrine neoplasm) is presented. The effects of the starch, protein, and soluble oligosaccharides contents in wheat bran on the extracellular biomass-hydrolyzing enzymes activities released by Penicillium decumbens mycelia grown in batch fermentations have been examined. This study was performed to evaluate the efficacy of interscalene regional blocks and infusion pumps for postoperative pain control after arthroscopic subacromial decompression with or without arthroscopic rotator cuff repair.

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Strictly defined, they include carcinomas that transform from the chronic open wounds of pressure sores or burn scars. Traumatic brain injury frequently elicits epileptic seizures hours or days after the impact.

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Some strategies have shown positive but only short-term effects, as consumers or other stakeholders do not accept them sufficiently in the long term. Monozygosity was proved by the standard genetic characteristics. The balance of risks and benefits of feeding preterm formulas versus supplemented maternal and donor breast milk for preterm infants, however, is uncertain. We sought to assess the experiences, growth, and distribution of accredited headache medicine fellowships since accreditation began in 2007, and to examine the number and current practice locations of fellows graduated from those programs.

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Speech therapy is needed to eliminate any compensatory articulation productions developed prior to prosthetic management. A significant relationship was found between the pH recordings from the fourth part of the duodenum and the degree of residual fat malabsorption while taking enteric-coated enzyme supplements.

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We propose that synapsin I links synaptic vesicles to actin filaments in the presynaptic nerve terminal and that these interactions are modulated by the reversible phosphorylation of synapsin I through various signal transduction pathways. Surgical resection of lung metastases is an established therapy for a large number of primary tumors, but there is some controversy about prognostic factors for long-term survival. Differential diagnosis of cervical lymphadenopathy with intranodal color Doppler flow signals in patients with oral squamous cell carcinoma. Characterization of a novel and genetically different small infective variant of Piscirickettsia salmonis. Such ocular changes may arise after local or systemic drug application.

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The aim of this review was to determine whether dexmedetomidine alone provided satisfactory conditions for children undergoing magnetice resonance imaging (MRI). Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer.

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This study included forty patients (Group 1) with symptomatic LSS in whom intra-articular spacers have been implanted along with microdecompression (MD) of the neural structures. Modulation of aromatase activity and expression by environmental chemicals. Resolution of hepatitis C virus-induced steatosis improves tolerability of antiretroviral drugs associated with hepatotoxicity in an HIV-infected individual. Long-term urinary catheter users experience repeated problems with catheter-related urinary tract infection and blockage of the device, yet little has been reported of the patterns and relationships among relevant catheter variables. Questionnaires modified from the Medical Oncology Status in Europe Survey dealing with oncology structure, resources, research, and patterns of care given by medical oncologists were selected.

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These findings require a reappraisal of the hypothesis of a dopaminergic self-stimulation system, although they are not in conflict with the idea that dopaminergic manipulations may affect self-stimulation through some more general regulatory influence on operant responding. The ability to induce delayed hypersensitivity reaction to VZV antigens was observed after immunization of guinea pigs with gE- and/or gB-expressing VVs. Single-nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell but not solid-organ transplant (SOT) recipients. Near infrared spectroscopy (NIRS) has been used to assess muscle tissue oxygenation (StO(2)) in haemorrhagic and septic shock. Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.

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Variability of a peripheral dose among various linac geometries for second cancer risk assessment. However, the prevalence and clinical impact of EDS among migraineurs at the population level have rarely been reported. Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms.

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We found that time derivatives can be computed by the chemotaxis system for input frequencies below 0.006 Hz at 22 degrees C and below 0.018 Hz at 32 degrees C. A wide range of organisms, including 11 viruses, eight bacterial species, one internal arthropod species, representatives from eight genera of protozoan, 21 genera of nematode, seven genera of cestode, eight genera of trematode and six genera of external arthropod (mites, ticks and louse), have been reported in literature spanning over a century of research. Stereoselective synthesis of isoxazolidines through Pd-catalyzed carboetherification of N-butenylhydroxylamines.

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Physician and patient benefit-risk preferences from two randomized long-acting injectable antipsychotic trials. Radio-receptor assay of plasma samples from patients and controls. Neither WT mice treated with murine APC nor EPCR-TgN were protected against AngII-induced thrombus development. Influence of polymorphism of glutathione S-transferase T1 on Chinese infertile patients with varicocele.

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The computational efficiency of this step is a deciding factor in design of alignment strategies for large sets of noisy data and in development of three-dimensional structure refinement methods. Although the patient was continuously treated for her lung infection by different physicians for more than twenty years, the diagnosis CF had been missed. Tomographic findings of gastric gastrointestinal stromal tumor and correlation with the mitotic index.

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Several techniques have been proposed to measure translation of the distal radioulnar joint on computed tomography scans, but the criteria for diagnosing abnormal subluxation have not been standardized. These findings underscore the role of HO-1 induced STAT3 in modulating PI3K/PTEN in liver IRI cascade. Compared to the Ortho group, the Stroke group had significantly worse performance on the TCT in terms of number of trials to criterion, delayed recall, and recognition discrimination.

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Chest radiography showed right-sided pleural effusion with an apparent normal superior mediastinum. The amino acids are listed along with their 3-letter and 1-letter codes, molecular weights, accessibility surface area, hydrophobicity, relative mutability and surface probability.

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The methodical approaches suggested enabled not only to avoid some errors during estimation of the prostaglandin-synthetase activity in individual platelets but also to increase accuracy, sensitivity and specificity of the procedure as compared with similar methods. The specification of the mesoderm and endoderm is of particular interest as the mesoderm is induced from the endoderm, potentially from an underlying bipotential group of cells, the mesendoderm. Long term efficacy and withdrawal of zopiclone: a sleep laboratory study. Recommendations by dental staff and use of toothpicks, dental floss and interdental brushes for approximal cleaning in an adult Swedish population.

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By using the replica plating method to test for the beta-hemolytic characteristic of all the colonies growing on Listeria-selective agars instead of picking 3 to 10 suspected colonies for further testing, we recovered Listeria monocytogenes from 59 of 142 Listeria-selective agar plates which contained colonies of hemolytic and nonhemolytic Listeria species and were negative when tested by conventional colony picks. Transection of the sling material on either side of the urethra should correct retention while preserving continence. The use of a comprehensive diagnostic panel for respiratory viral infections may be useful to clarify the epidemiology and clinical impact of viral pathogens in hospitalized adult patients. In this work it is shown that these limitations can be overcome by incorporating on-line prospective registration into the data acquisition protocol. The aim of this study was to compare the ability of quantitative light-induced fluorescence (QLF) and surface microhardness (SMH) to measure the remineralization of enamel subsurface lesions, using a pH-cycling model including treatment with 0-ppm, 550-ppm or 1,100-ppm sodium fluoride (NaF) dentifrices.

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Microbial-derived natural products have wide-ranging applications, especially as chemotherapeutics for various diseases and disorders. We assessed the hemodynamics of hydroxocobalamin (OHCo) and normal saline (NS) by the IO route. Changes in steroid hormone profiles and ovarian histology during salmon pituitary-induced vitellogenesis and ovulation in female New Zealand longfinned eels, Anguilla dieffenbachii gray. Numerical bioelectromagnetic simulation methods for penetrating electromagnetic fields facilitate the calculation of field components in biological entities.

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Given the difficulties surrounding the analysis of shark caudal fins in vivo, little is known about changes in tail shape related to ontogeny and sex in sharks. Mutated CTSF in adult-onset neuronal ceroid lipofuscinosis and FTD.

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Development of daptomycin nonsusceptibility with heterogeneous vancomycin-intermediate resistance and oxacillin susceptibility in methicillin-resistant Staphylococcus aureus during high-dose daptomycin treatment. Of the 11 cases monitored, oculomotor and abducent nerves were identified in all cases, but the trochlear nerve could not be definitively identified. We present a simple dynamic model and show that structural remodeling of the vessel radius by rearrangement of the wall material around a lumen of a different diameter and driven by differences in SMC activation can lead to vascular structures similar to those observed experimentally under various conditions. It associates noncovalently with the cytoplasmic domains of the CD4 and CD8 coreceptor molecules and has been implicated in TCR signaling in mature T cells. Selective removal (incomplete) to soft dentin in deep carious lesions has greater success rates than stepwise excavation.

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Depression status and sleep quality are strongly influenced by diabetic complications and DM duration in elderly patients. It is concluded that cytokine-induced beta-cell signaling is associated with the induction of iNOS but not with enhanced SMase activities. Future research should adopt multiple measures of EF to provide clear evidence on the associations between EF and rumination.

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Given the paucity of tumor-type and site-specific data, the authors evaluated the incidence of postoperative seizures in patients with convexity meningiomas and no prior seizures. Ribavirin was found to beneficial in reducing the morbidity in our patients. We conclude that prevention of cell death in the sensory epithelium is essential for any attempt to restore the auditory function in DFNB1 patients. Low educational level, low disposable income, being divorced or never married, and living in a single-person household, all increase the risk of advanced stage penile cancer, but not lymph node or distant metastases.

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Given the 12-A overall length of the blockers and the alpha-helical conformation of M2 in the open state, the binding site for both blockers extends from alphaVal255 down to alphaSer248. The hairpin is found to fold heterogeneously on sub-microsecond timescales, with the relative position of the tryptophan side chains driving the selection of the specific pathway. Cluster analyses were used to identify subgroups of mothers regarding maternal perceived uncertainty and distress. Significant positive relationships were observed between SHP2 expression and bromodeoxyuridine uptake in SMCs stimulated by FBS, platelet-derived growth factor, or insulin-like growth factor-1. Low rectal cancer: classification and standardization of surgery.

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Gross metastatic nodes reveal significant prognostic information and guide the use of adjuvant therapy in affected patients. To determine the hospital characteristics and barriers that influence the rates of adoption of these practices. Long-term Outcome and Analysis of Dysfunction of Transjugular Intrahepatic Portosystemic Shunt Placement in Chronic Primary Budd-Chiari Syndrome. The present findings suggest, for the first time, that mtDNA copy number may be associated with earlier events and may therefore be further explored as a potential biomarker for follow-up of TTR-FAP Val30Met carriers. Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors.

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There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Work on motor cortex has focused on movement generation, but correlations between vibrissa motor cortex activity and whisking are weak. Cost-utility analysis of Canadian tailored prophylaxis, primary prophylaxis and on-demand therapy in young children with severe haemophilia A.

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The adventitia, comprising wavy collagen fibers punctuated by straight elastic fibers, thinned under pressure as the collagen network straightened and pulled taut. Subsequently, in March 2005, the patient developed fever, pancytopenia and liver dysfunction, and was admitted to Saitama Social Insurance Hospital. Mechanistic studies reveal that dioxygen could be activated through an ET and a SET pathway, forming active peroxides in situ, which are vital for the key step of the reaction, i.e. These findings shed light on the mechanisms by which HPV induces genomic instability and hold promise for the identification of drug targets. For chemical analysis absorption spectroscopy in visible light and atomic absorption spectroscopy were used.

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Glow in the dark: fluorescent proteins as cell and tissue-specific markers in plants. Guidelines for the asthmatic patient during air pollution episodes.

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The disadvantages related to the cycle phases make male rats more appropriate donor animals for the test system developed. Experimental analysis to utilize the solid wastes in brick production. Recent findings point to the emerging role of non-protein-coding regions of the genome in their contribution to the progression of cancer and tumor formation.

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Future studies are required to evaluate the use of our score in a prospective setting. Tattoo pigments released or modified by laser therapy may trigger transient immunoreactivity in susceptible individuals. An important question regarding each of these effects is whether the cholesterol exerts its influence by binding directly to membrane proteins or by changing the properties of lipid bilayers. HIV-1 replicates in monocytoid cells to an extent that is influenced by their differentiation status and modulated by exogenous stimulations.

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Epithelial-myoepithelial carcinoma--a technique to identify myoepithelial cells Internuclear Bridging of Erythroid Precursors in the Peripheral Blood Smear of a Patient with Primary Myelofibrosis.

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Interestingly, the overexpression of ORC1N(1-238) compromises the binding of Sir2 at the subtelomeric loci and var gene promoters consistent with de-repression of some var genes. Ocular manifestations of Stevens-Johnson syndrome and their management.

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Anthelmintic efficacy of gold nanoparticles derived from a phytopathogenic fungus, Nigrospora oryzae. Role of carcinoembryonic antigen in the management of advanced colorectal cancer. Preparation and characterization of decellularized tendon slices for tendon tissue engineering. While globe-salvage still relies heavily on intravenous chemotherapy, tumors in advanced stage that failed chemotherapy are now referred for intra-arterial chemotherapy (IAC) to avoid enucleation. The purpose of this study is to assess the utility of web-based mobile technology monitoring tool, for ensuring linkages, and tracking of HIV-exposed child until 18 months of age.

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The implementation of the Community Treatment Order (CTO) has created controversy surrounding its beneficence. Diosgenin is a precursor of steroid hormones, which can be found in several plant species.

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Time-of-addition experiments confirmed that MA affects a late event in the multiplication cycle of HSV-1. With the predicted increase in both of these populations in the coming decades, it is imperative to evaluate potential interventions that are designed to help older cancer patients compensate for the additive burden of this disease and its treatment on age-related taste and smell losses.

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In this review, we summarize warfarin interactions chart current state of the art concerning microbubble-cell interactions and cellular effects leading to sonoporation and its application for gene delivery. Analysis of the assemblies by Foerster resonance energy transfer (FRET) using acceptor bleaching demonstrated mostly annexin-specific self-assembly.

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Efficient blue phosphorescent organic light-emitting diodes by tuning iridium(III) phenylpyridine complexes. These denatured cytochromes P-450 were capable of displacing from the immunoaffinity matrices epitopically related cytochromes P-450 that retained aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-deethylase activities. Behavioural effects of A1/A2 adenosine-selective antagonists in the mouse. Discovery of the aryl heterocyclic amine insecticides: synthesis, insecticidal activity, field results, mode of action and bioavailability of a leading field oropram 20 mg prednisone candidate. These data suggest that the coenzyme ring tilts in opposite directions upon noncovalent substrate binding and upon subsequent formation of the external aldimine.

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This study radiographically evaluated the buccastem max dose of ibuprofen performance of autologous platelet-rich plasma (PRP) applied in tooth sockets. Lentiviral vectors are now in clinical trials and a similar evolution of vector technology is anticipated.

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An analogous less-powerful flexor synergy exists during leg flexion. Adiponectin, resistin, leptin, and visfatin concentrations were measured by enzyme-linked immunosorbent assay in peripheral veins, arterial blood, hepatic veins, and portal veins in 50 patients with liver cirrhosis undergoing transjugular intrahepatic portosystemic shunt implantation, in 6 patients virex 256 ingredients with normal liver function, and in fasted and fed rats. Isotopically resolved photoelectron imaging unravels complex atomic autoionization dynamics by two-color resonant ionization. Urinary tract infections (UTIs) are common bacterial infections, particularly in women. The high degree of sequence homology between the KMP-11 proteins from both parasites suggests that the KMP-11 protein from T.

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Intensive care unit admission predicts hospital readmission in pediatric trauma. The aim of this study was to assess the medikament ranitic 300 mg factors related to new diabetes in hypertensive. We conclude with recommendations about current and future directions regarding how to incorporate and translate biological findings into improved therapies for individuals with nonsubstance and substance addictions.

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This research developed a composite migration history score, using data on birth places of subjects, and their parents and grand parents, and the length of residence in US from 390 overweight Mexican American women. MATLAB code is available at (github). Evidence is strongest for the NOD mouse model where cialis vs viagra dosage comparison blocking immune responses to insulin prevents diabetes, and insulin peptides can be utilized to induce diabetes. Mice with mutations at the downless (dl) locus have defects in hair follicle, tooth, sweat gland, preputial gland, Meibomian gland, and tail development. While most bone defects heal spontaneously, critical size defects caused by major trauma/malignant tumor and osteonecrosis of femoral head in young adults pose a great challenge in treatment.

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The aim of the current study was to assess the efficacy of a lifestyle intervention program using the Japanese-style healthy plate on weight reduction in overweight and obese diabetic Japanese subjects. Albeit less buy zanprol 10mg tablets omeprazole and dementia effective than full activity, either Rb- or p300-binding activity of E1A was sufficient for the abrogation of PMA-mediated growth arrest. The effect of various individual lipids and media composition was also evaluated relative to the adhesional, immersional, and spreading stages of wetting. Although DILI and PBC share some similar laboratory tests (biochemical and immunological indexes) and pathological findings, they also show some distinct characteristics, which are helpful to the differential diagnosis of the two diseases. Green tea catechins, especially epigallocatechin-3-gallate (EGCG), have been associated with cancer prevention and treatment.

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The results indicate that diet cannot explain the low blood cholesterol-cancer association in men. Exposure to chronic life-threatening stress resulted in more pregnancy complications and in particular more premature membrane ruptures. By the reverse transcription polymerase chain reaction method, three calpastatin cDNAs, full-length domains L and 1, and two natural mutants with deletions in either exon 3 or in both exons 3 and 5, were cloned from human fibroblast WI-38 cell line mRNA. Numerical intelligence, verbal competence and intelligence in preschool children with cochlear implants: our findings in a clinical sample. Although transcriptional effects are important, alterations in mRNA decay also play a tadacip vs ceebis tadalafil major role in achieving rapid and massive changes in mRNA abundance.

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Grade I and II injuries were successfully managed by conservative treatment. The results provided no evidence of a defect in cell migration or in the phagocytic activity of macrophages in polycythaemia vera. whooping cough pertussis treatment erythromycin Clinical, rhinorheometric and sonomanometric study of the effects of F.F.

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Report on the sterilizing effect of Chinese iodophore on public tableware From nonirradiated intestine, only Sox9-EGFP Low cells exhibited ISC characteristics of forming organoids in culture, whereas during regeneration rabeprazole sodium and domperidone capsules cipla webmail both Sox9-EGFP Low and High cells formed organoids. The theoretical plate number on averaging all the sample peaks was significantly decreased from 283,000 to 19,000/m. The quality and related parameters of sleep before and after treatment were evaluated with a multi-channel sleep detector.